Technology Process of N1-methyl-2-amino-N5-<4-<(4-methoxyphenyl)sulfonyl>benzyl>-5,6,7,8-tetrahydro-1H-imidazo<4,5-g>quinoline
There total 15 articles about N1-methyl-2-amino-N5-<4-<(4-methoxyphenyl)sulfonyl>benzyl>-5,6,7,8-tetrahydro-1H-imidazo<4,5-g>quinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: FeCl3 / nitrobenzene / 2 h / 120 °C
2: 82 percent / 5N KOH / ethanol / 1 h / 80 °C
3: 92 percent / K2CO3 / CHCl3 / 4 h / Heating
4: 64 percent / N-bromosuccinimide / CCl4 / 1 h / Heating; Irradiation
5: 82 percent / diisopropylethylamine / dimethylformamide / 5 h / 70 °C
6: 49 percent / K2CO3 / dimethylformamide / 48 h / 80 °C
7: 32 percent / 3 N aq. HCl / 5.5 h / 60 °C
8: hydrazine / Raney nickel / methanol; tetrahydrofuran; H2O / 1 h / Heating
9: 56 percent / acetonitrile; methanol / 2 h / 70 °C
With
hydrogenchloride; potassium hydroxide; N-Bromosuccinimide; iron(III) chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; hydrazine;
nickel;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; chloroform; water; nitrobenzene; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00083a007
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 77 percent / CH2Cl2 / 0.17 h / 25 °C
2: 85 percent / H2 / PtO2 / acetic acid / 1.5 h / 1551.4 Torr
3: 98percent H2SO4, 70percent HNO3 / -10 °C
4: 82 percent / diisopropylethylamine / dimethylformamide / 5 h / 70 °C
5: 49 percent / K2CO3 / dimethylformamide / 48 h / 80 °C
6: 32 percent / 3 N aq. HCl / 5.5 h / 60 °C
7: hydrazine / Raney nickel / methanol; tetrahydrofuran; H2O / 1 h / Heating
8: 56 percent / acetonitrile; methanol / 2 h / 70 °C
With
hydrogenchloride; sulfuric acid; hydrogen; nitric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; hydrazine;
platinum(IV) oxide; nickel;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00083a007