2,2-dichloro-1,1-difluoro-3-phenyl-cyclobutane

Base Information

• Chemical Name: 2,2-dichloro-1,1-difluoro-3-phenyl-cyclobutane
• CAS No.: 1716-70-7
• Molecular Formula: C₁₀H₈Cl₂F₂
• Molecular Weight: 237.076
• Mol file: 1716-70-7.mol

Synonyms:2,2-dichloro-1,1-difluoro-3-phenyl-cyclobutane

Chemical Property of 2,2-dichloro-1,1-difluoro-3-phenyl-cyclobutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-dichloro-1,1-difluoro-3-phenyl-cyclobutane

There total 1 articles about 2,2-dichloro-1,1-difluoro-3-phenyl-cyclobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 1,1'-dichloro-2,2'-difluoroethene (79-35-6) → 2,2-dichloro-1,1-difluoro-3-phenyl-cyclobutane (1716-70-7)

Guidance literature:

at 112 ℃; for 43h;

DOI:10.1021/ja00076a024

Reference yield: 83.0%

2,2-dichloro-1,1-difluoro-3-phenyl-cyclobutane (1716-70-7) → 1,1-difluoro-2-chloro-3-phenyl-2-cyclobutene (320-00-3)

Guidance literature:

With potassium hydroxide; In ethanol; for 21h; Ambient temperature;

DOI:10.1021/ja00076a024

Reference yield:

2,2-dichloro-1,1-difluoro-3-phenyl-cyclobutane (1716-70-7) → (1s,3s)-3-phenylcyclobutanol (150639-15-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / KOH / aq. ethanol / 21 h / Ambient temperature

2: 78 percent / conc. H₂SO₄ / 0.28 h / Heating

3: 96 percent / AcONa, H₂ / Pd/C / methanol

4: 80 percent / LiAlH₄ / diethyl ether

With potassium hydroxide; lithium aluminium tetrahydride; sulfuric acid; hydrogen; sodium acetate; palladium on activated charcoal; In methanol; diethyl ether; ethanol;

DOI:10.1021/ja00076a024

upstream raw materials:

styrene

1,1'-dichloro-2,2'-difluoroethene

Downstream raw materials:

1,1-difluoro-2-chloro-3-phenyl-2-cyclobutene

1,1-difluoro-3-phenyl-cyclobutane

3-Phenylcyclobutanone

trans-3-phenylcyclobutanol tosylate

Refernces