biphenyl-4-propiophenone

Base Information

• Chemical Name: biphenyl-4-propiophenone
• CAS No.: 102477-83-8
• Molecular Formula: C21H18 O
• Molecular Weight: 286.373
• Mol file: 102477-83-8.mol

Synonyms:Propiophenone,3-(4-biphenylyl)- (6CI)

Chemical Property of biphenyl-4-propiophenone

Chemical Property:

• PSA: 17.07000
• LogP: 3.94630

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of biphenyl-4-propiophenone

There total 10 articles about biphenyl-4-propiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

biphenyl-4-yl methanol (3597-91-9) + acetophenone (98-86-2) → 3-([1,1′-biphenyl]-4-yl)-1-phenylpropan-1-one (102477-83-8)

Guidance literature:

With potassium phosphate tribasic trihydrate; C₃₉H₃₂Cl₂N₅PRu; In tert-Amyl alcohol; at 120 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.8b00013

Reference yield: 88.0%

3-(biphenyl-4-yl)-1-phenylprop-2-en-1-one (36047-01-5,2403-28-3) → 3-([1,1′-biphenyl]-4-yl)-1-phenylpropan-1-one (102477-83-8)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; silica gel; In toluene; at 70 ℃; for 17h; Inert atmosphere; Darkness;

DOI:10.1021/jm9001499

Reference yield: 85.0%

p-vinylbiphenyl (2350-89-2) + diethyl 4-benzoyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate → 3-([1,1′-biphenyl]-4-yl)-1-phenylpropan-1-one (102477-83-8)

Guidance literature:

With caesium carbonate; In acetonitrile; at -78 - 20 ℃; for 10h; Inert atmosphere; Irradiation; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.9b04595

upstream raw materials:

3-(biphenyl-4-yl)-1-phenylprop-2-en-1-one

biphenyl-4-yl methanol

acetophenone

1-Phenylethanol

Downstream raw materials:

ethyl 5-(biphenyl-4-yl)-3-phenylpent-2-enoate

ethyl 5-(biphenyl-4-yl)-3-phenylpent-2-enoate

p-vinylbiphenyl

Refernces

• 1、 Zhu, Guanxin,Duan, Zheng-Chao,Zhu, Haiyan,Ye, Dongdong,Wang, Dawei. "Selective C-C bonds formation, N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite". supporting information. p. 266 - 270. Retrieved 2021/08/06.
• 2、 Dong, Guangbin,Xu, Yan,Zhou, Xukai. "Olefination via Cu-Mediated Dehydroacylation of Unstrained Ketones". supporting information. p. 20042 - 20048. Retrieved 2021/12/03.