trans-4-PHENYLCHALCONE oxide

Base Information

• Chemical Name: trans-4-PHENYLCHALCONE oxide
• CAS No.: 36047-01-5
• Molecular Formula: C21H16 O
• Molecular Weight: 284.357
• Hs Code.: 2914399090
• Mol file: 36047-01-5.mol

Synonyms:2-Propen-1-one,3-[1,1'-biphenyl]-4-yl-1-phenyl-, (E)-; trans-4-Phenylchalcone

Chemical Property of trans-4-PHENYLCHALCONE oxide

Chemical Property:

• PSA: 17.07000
• LogP: 5.24970

Purity/Quality:

99% ^*data from raw suppliers

trans-4-Phenylchalcone oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-4-PHENYLCHALCONE oxide

There total 14 articles about trans-4-PHENYLCHALCONE oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2E)-3-(4-bromophenyl)-1-phenylprop-2-en-1-one (22966-09-2) + phenylboronic acid (98-80-6) → (E)-3-[(1,1′-biphenyl)-4-yl]-1-phenylprop-2-en-1-one (36047-01-5)

Guidance literature:

With C₂₅H₁₆O₆*C₄H₁₁N*H₂O; palladium diacetate; potassium carbonate; In water; at 80 ℃; for 1 - 2h;

DOI:10.1016/j.tetlet.2016.07.028

Reference yield: 86.0%

phenylacetylene (536-74-3) + 4-Phenylbenzaldehyde (3218-36-8) → (E)-3-[(1,1′-biphenyl)-4-yl]-1-phenylprop-2-en-1-one (36047-01-5)

Guidance literature:

With amberlyst-15 resin; at 90 ℃; Microwave irradiation; Neat (no solvent);

DOI:10.3762/bjoc.7.198

Reference yield: 79.0%

4-bromo-benzaldehyde (1122-91-4) + acetophenone (98-86-2) + phenylboronic acid (98-80-6) → (E)-3-[(1,1′-biphenyl)-4-yl]-1-phenylprop-2-en-1-one (36047-01-5)

Guidance literature:

With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; In water; at 90 ℃; for 1.5h; Reagent/catalyst; Concentration; Solvent; Green chemistry;

DOI:10.1002/chem.201303069

upstream raw materials:

acetophenone

4-Phenylbenzaldehyde

3-(4-chlorophenyl)-1-phenylprop-2-en-1-one

phenylmagnesium bromide

Downstream raw materials:

3-([1,1′-biphenyl]-4-yl)-1-phenylpropan-1-one

2-(3-(biphenyl-4-yl)-1-phenylallylidene)hydrazinecarboximidamide

p-vinylbiphenyl

4-([1,1’-biphenyl]-4-yl)butan-2-one

Refernces

• 1、 Kumar, Togiti Uday,Thigulla, Yadagiri,Rangan, Krishnan,Bhattacharya, Anupam. "Application of Polyphosphoric Acid-Mediated Acyl Migration for Regiospecific Synthesis of Diverse 2-Acylpyrroles from Chalcones". supporting information. p. 1283 - 1290. Retrieved 2019/03/07.
• 2、 Qi, Xinxin,Lai, Ming,Zhu, Min-Jie,Peng, Jin-Bao,Ying, Jun,Wu, Xiao-Feng. "1-Arylvinyl formats: A New CO Source and Ketone Source in Carbonylative Synthesis of Chalcone Derivatives". . p. 5252 - 5255. Retrieved 2019/02/25.