1-(4-(methyl carboxylate) phenyl) pyrrole

Base Information

• Chemical Name: 1-(4-(methyl carboxylate) phenyl) pyrrole
• CAS No.: 23351-08-8
• Molecular Formula: C₁₂H₁₁NO₂
• Molecular Weight: 201.225
• Hs Code.: 2933998090
• Mol file: 23351-08-8.mol

Synonyms:1-(4-(methyl carboxylate) phenyl) pyrrole

Chemical Property of 1-(4-(methyl carboxylate) phenyl) pyrrole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-Pyrrol-1-yl-benzoicacidmethylester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-(methyl carboxylate) phenyl) pyrrole

There total 9 articles about 1-(4-(methyl carboxylate) phenyl) pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + 4-(1H-pyrrole-1-yl)benzoic acid (22106-33-8) → 1-(4-(methyl carboxylate) phenyl) pyrrole (23351-08-8)

Guidance literature:

With sulfuric acid; for 12h; Reflux;

DOI:10.1016/j.jcat.2021.08.020

Reference yield: 84.0%

pyrrole (109-97-7,30604-81-0) + methyl 4-iodobenzoate (619-44-3) → 1-(4-(methyl carboxylate) phenyl) pyrrole (23351-08-8)

Guidance literature:

With palladium; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 130 ℃; for 24h; Inert atmosphere;

DOI:10.1039/d0nj02129f

Reference yield: 82.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + 4-methoxycarbonyl aniline (619-45-4) → 1-(4-(methyl carboxylate) phenyl) pyrrole (23351-08-8)

Guidance literature:

In acetic acid; at 150 ℃; for 0.166667h; Microwave irradiation; Sealed tube;

DOI:10.1021/jacs.0c04450

upstream raw materials:

4-(3,6-Dihydro-[1,2]oxazin-2-yl)-benzoic acid methyl ester

1-(trimethylsilyl)-1H-pyrrole

4-methoxycarbonylphenyl bromide

1-pyrrolyl-1-methylsilacyclobutane

Downstream raw materials:

5-(4-(1H-pyrrol-1-yl)phenyl)-1,3,4-oxadiazole-2-thiol

4-(1H-pyrrol-1-yl)benzoic acid hydrazide

Refernces

• 1、 Balasubramaniam, Bhuvaneshwari,Dhara, Partha,Gupta, Raju K.,Kundu, Sabuj,Panja, Dibyajyoti,Sau, Anirban. "Utilization of caffeine carbon supported cobalt catalyst in the tandem synthesis of pyrroles from nitroarenes and alkenyl diols". . p. 244 - 254. Retrieved 2021/09/07.
• 2、 Roman, Gheorghe,Bost?naru, Andra-Cristina,N?stas?, Valentin,Mare?, Mihai. "Design, synthesis, and evaluation of the antimycobacterial activity of 3-mercapto-1,2,4-triazole–pyrrole hybrids". . p. 531 - 546. Retrieved 2019/10/02.