2-(3-Bromopropyl)-2-propyl-1,3-dioxolane

Base Information

• Chemical Name: 2-(3-Bromopropyl)-2-propyl-1,3-dioxolane
• CAS No.: 101650-18-4
• Molecular Formula: C9H17 Br O2
• Molecular Weight: 237.137
• Mol file: 101650-18-4.mol

Synonyms:2-(3-bromopropyl)-2-propyl-1,3-dioxolane;SCHEMBL6739159;INRNFOINQWRSFI-UHFFFAOYSA-N

Chemical Property of 2-(3-Bromopropyl)-2-propyl-1,3-dioxolane

Chemical Property:

• PSA: 18.46000
• LogP: 2.70470
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 236.04119
• Heavy Atom Count: 12
• Complexity: 122

Purity/Quality:

97% ^*data from raw suppliers

1-BROMO-3-ETHYLENEDIOXY-HEPTANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1(OCCO1)CCCBr

Technology Process of 2-(3-Bromopropyl)-2-propyl-1,3-dioxolane

There total 1 articles about 2-(3-Bromopropyl)-2-propyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

7-bromo-4-heptanone (20434-21-3) + ethylene glycol (107-21-1) → 2-(3-bromopropyl)-2-propyl-1,3-dioxolane (101650-18-4)

Guidance literature:

DOI:10.1016/S0040-4020(01)96546-9

Reference yield: 100.0%

2-(3-bromopropyl)-2-propyl-1,3-dioxolane (101650-18-4) + 3-benzyl-3,7-diaza-bicyclo[3,3,1]nonane (69407-32-5) → 3-benzyl-7-[3-(2-propyl-1,3-dioxolan-2-yl)propyl]-3,7-diazabicyclo[3.3.1]nonane (313476-72-1)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating / reflux;

Reference yield: 96.0%

7-methoxy-2,3,3a,5-tetrahydro-1H-benzo[d]pyrrolo[2,1-b][1,3]oxazine + 2-(3-bromopropyl)-2-propyl-1,3-dioxolane (101650-18-4) → (5-methoxy-2-(2-(3-(2-propyl-1,3-dioxolan-2-yl)propyl)pyrrolidin-1-yl)phenyl)methanol (1374604-05-3)

Guidance literature:

2-(3-bromopropyl)-2-propyl-1,3-dioxolane; With magnesium; In tetrahydrofuran; at 0 - 50 ℃; Inert atmosphere;

7-methoxy-2,3,3a,5-tetrahydro-1H-benzo[d]pyrrolo[2,1-b][1,3]oxazine; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201108639

upstream raw materials:

7-bromo-4-heptanone

ethylene glycol

Downstream raw materials:

ester methylique de l'acide (N-benzyloxycarbonyl) amino-2 oxo-8 undecanoique

2-Benzyloxycarbonylamino-7-(2-propyl-[1,3]dioxolan-2-yl)-heptanoic acid methyl ester

3-benzyl-7-[3-(2-propyl-1,3-dioxolan-2-yl)propyl]-3,7-diazabicyclo[3.3.1]nonane

(5-methoxy-2-(2-(3-(2-propyl-1,3-dioxolan-2-yl)propyl)pyrrolidin-1-yl)phenyl)methanol

Refernces

• 1、 Bajgrowicz, J. A.,Hallaoui, A. El,Jacquier, R.,Pigiere, Ch.,Viallefont, Ph.. "LES ORGANOCUPRATES DANS UNE NOUVELLE SYNTHESE D'AMINOACIDES ENANTIOMERIQUEMENT PURS". . p. 1833 - 1845. Retrieved 2007/10/02.