ester methylique de l'acide (N-benzyloxycarbonyl) amino-2 oxo-8 undecanoique

Base Information

• Chemical Name: ester methylique de l'acide (N-benzyloxycarbonyl) amino-2 oxo-8 undecanoique
• CAS No.: 101650-22-0
• Molecular Formula: C₂₀H₂₉NO₅
• Molecular Weight: 363.454
• Mol file: 101650-22-0.mol

Synonyms:

Chemical Property of ester methylique de l'acide (N-benzyloxycarbonyl) amino-2 oxo-8 undecanoique

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ester methylique de l'acide (N-benzyloxycarbonyl) amino-2 oxo-8 undecanoique

There total 6 articles about ester methylique de l'acide (N-benzyloxycarbonyl) amino-2 oxo-8 undecanoique which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-Benzyloxycarbonylamino-7-(2-propyl-[1,3]dioxolan-2-yl)-heptanoic acid methyl ester (101650-12-8) → ester methylique de l'acide (N-benzyloxycarbonyl) amino-2 oxo-8 undecanoique (101650-22-0)

Guidance literature:

deprotection;

DOI:10.1016/S0040-4020(01)96546-9

Reference yield:

7-bromo-4-heptanone (20434-21-3) → ester methylique de l'acide (N-benzyloxycarbonyl) amino-2 oxo-8 undecanoique (101650-22-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent

2: 71 percent Spectr_. / Li / diethyl ether / 1.) 0-5 deg C, 2.) RT, 1 h

3: 1.) CuI, butyl sulfide / 1.) Et₂O, -60 deg C, 30 min; 2.) Et₂O, -60 deg C, 3 h

4: 78 percent / deprotection

With copper(l) iodide; Dibutyl sulfide; lithium; In diethyl ether;

DOI:10.1016/S0040-4020(01)96546-9

Reference yield:

2-(3-bromopropyl)-2-propyl-1,3-dioxolane (101650-18-4) → ester methylique de l'acide (N-benzyloxycarbonyl) amino-2 oxo-8 undecanoique (101650-22-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent Spectr_. / Li / diethyl ether / 1.) 0-5 deg C, 2.) RT, 1 h

2: 1.) CuI, butyl sulfide / 1.) Et₂O, -60 deg C, 30 min; 2.) Et₂O, -60 deg C, 3 h

3: 78 percent / deprotection

With copper(l) iodide; Dibutyl sulfide; lithium; In diethyl ether;

DOI:10.1016/S0040-4020(01)96546-9

upstream raw materials:

2-Benzyloxycarbonylamino-7-(2-propyl-[1,3]dioxolan-2-yl)-heptanoic acid methyl ester

2-Amino-4-iodo-butyric acid methyl ester

7-bromo-4-heptanone

methyl N^α-benzyloxycarbonylamino-γ-iodobutyrate

Refernces