1-(3-BROMOPROPYL)PYRROLE

Base Information

• Chemical Name: 1-(3-BROMOPROPYL)PYRROLE
• CAS No.: 100779-91-7
• Molecular Formula: C7H10 Br N
• Molecular Weight: 188.067
• Hs Code.: 2933990090
• Mol file: 100779-91-7.mol

Synonyms:1-(3-Bromopropyl)-1H-pyrrole;1-(3-Bromopropyl)pyrrole; 1-Bromo-3-(1-pyrrolyl)propane;N-(3-Bromopropyl)pyrrole; N-(w-Bromopropyl)pyrrole

Chemical Property of 1-(3-BROMOPROPYL)PYRROLE

Chemical Property:

• Vapor Pressure: 0.135mmHg at 25°C
• Refractive Index: 1.538
• Boiling Point: 224.6°Cat760mmHg
• PKA: -3.18±0.70(Predicted)
• Flash Point: 89.7°C
• PSA: 4.93000
• Density: 1.34g/cm³
• LogP: 2.27310
• Storage Temp.: 0-10°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(3-Bromopropyl)pyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-BROMOPROPYL)PYRROLE

There total 5 articles about 1-(3-BROMOPROPYL)PYRROLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-1H-pyrrole → 1-(3-bromopropyl)-1H-pyrrole (100779-91-7)

Guidance literature:

With dibromotriphenylphosphorane; In dichloromethane; for 0.25h;

DOI:10.1021/ol060447y

Reference yield: 64.0%

pyrrole (109-97-7,30604-81-0) + 1,3-dibromo-propane (109-64-8) → 1-(3-bromopropyl)-1H-pyrrole (100779-91-7)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jo00002a083

Reference yield: 63.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + 3-bromopropylamine hydrochloride (5003-71-4) → 1-(3-bromopropyl)-1H-pyrrole (100779-91-7)

Guidance literature:

With sodium acetate; In water; acetic acid; at 70 ℃; for 2.5h;

DOI:10.1016/j.elecom.2009.12.026

upstream raw materials:

cis,trans-2,5-dimethoxytetrahydrofuran

3-bromopropylamine hydrochloride

pyrrole

1,3-dibromo-propane

Downstream raw materials:

(R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid

(R)-methyl 1-(2-aminophenyl)-8-ethyl-8-vinyl-5,6,7,8-tetrahydroindolizine-3-carboxylate

Refernces

• 1、 Ribeiro, Adriana Santos,Kanazawa, Alice,Navarro, Daniela M. A. F.,Moutet, Jean-Claude,Navarro, Marcelo. "Synthesis of (R)-(-) and (S)-(+)-3-(1-pyrrolyl)propyl- N-(3,5- dinitrobenzoyl)-α-phenylglycinate and derivatives. A suitable chiral polymeric phase precursor". . p. 3735 - 3745. Retrieved 1999.
• 2、 Willicut, Robert J.,McCarley, Robin L.. "Electrochemical polymerization of pyrrole-containing self-assembled alkanethiol monolayers on Au". . p. 10823 - 10824. Retrieved 1994.
• 3、 Otten, Thomas,Darbre, Tamis,Cosnier, Serge,Abrantes, Luisa,Correia, Jorge,Keese, Reinhart. "Synthesis of Vitamin-B12 Derivatives with an Electropolymerizable Side Chain". . p. 1117 - 1126. Retrieved 1998.
• 4、 -. "A stimulus-responsive poly-pyrrole nano tube targeted drug carrier and its preparation method". Paragraph 0059; 0060. . Retrieved 2020/02/07.
• 5、 -. "FLAVIN DERIVATIVES". Page/Page column 164-165. . Retrieved 2011/10/31.