(2,5-Dimethoxy-2,5-dihydrofuran-2-yl)methanol

Base Information

• Chemical Name: (2,5-Dimethoxy-2,5-dihydrofuran-2-yl)methanol
• CAS No.: 19969-71-2
• Molecular Formula: C7H12 O4
• Molecular Weight: 160.17
• Hs Code.: 2932190090
• European Community (EC) Number: 620-999-2
• DSSTox Substance ID: DTXSID50515098
• Nikkaji Number: J27.265E
• Mol file: 19969-71-2.mol

Synonyms:(2,5-Dimethoxy-2,5-dihydrofuran-2-yl)methanol;19969-71-2;(2,5-dimethoxy-2H-furan-5-yl)methanol;2,5-Dihydro-2,5-dimethoxyfurfuryl alcohol;2 5-DIHYDRO-2 5-DIMETHOXYFURFURYL ALCOH&;SCHEMBL6992680;DTXSID50515098;AKOS015912721;SB61240;VS-12647;CS-0320730;(2,5-dimethoxy2,5-dihydro-2-furyl)methanol;2,5-Dihydro-2,5-dimethoxyfurfuryl alcohol, 97%;J-012905

Chemical Property of (2,5-Dimethoxy-2,5-dihydrofuran-2-yl)methanol

Chemical Property:

• Vapor Pressure: 0.0029mmHg at 25°C
• Refractive Index: n20/D 1.4590(lit.)
• Boiling Point: 114 °C14 mm Hg(lit.)
• PKA: 14.28±0.10(Predicted)
• Flash Point: 50 °F
• PSA: 47.92000
• Density: 1.164 g/mL at 25 °C(lit.)
• LogP: -0.11970
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 160.07355886
• Heavy Atom Count: 11
• Complexity: 157

Purity/Quality:

98% ^*data from raw suppliers

2,5-Dihydro-2,5-dimethoxyfurfuryl alcohol 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F
• Statements: 11
• Safety Statements: 16-33

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1C=CC(O1)(CO)OC

Technology Process of (2,5-Dimethoxy-2,5-dihydrofuran-2-yl)methanol

There total 7 articles about (2,5-Dimethoxy-2,5-dihydrofuran-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

(2-furyl)methyl alcohol (98-00-0,25212-86-6,93793-62-5) + methanol (67-56-1) → 2,5-dimethoxy-2-hydroxymethyl-2,5-dihydrofuran (19969-71-2)

Guidance literature:

With bromine; In diethyl ether; at -45 - -35 ℃; for 2h;

DOI:10.1016/S0040-4020(00)00846-2

Reference yield:

(2-furyl)methyl alcohol (98-00-0,25212-86-6,93793-62-5) + methyl hypobromite (28078-73-1) → 2,5-dimethoxy-2-hydroxymethyl-2,5-dihydrofuran (19969-71-2)

Guidance literature:

Reference yield:

(2-furyl)methyl alcohol (98-00-0,25212-86-6,93793-62-5) + methanol (67-56-1) + ammonium bromide → 2,5-dimethoxy-2-hydroxymethyl-2,5-dihydrofuran (19969-71-2)

Guidance literature:

Electrolysis;

upstream raw materials:

(2-furyl)methyl alcohol

methanol

methyl hypobromite

bromine

Downstream raw materials:

2-hydroxymethyl-4-formyl-2,5-dimethoxytetrahydrofurane

6-methoxy-2H-pyran-3(6H)-one

3-hydroxymethylpyridazine

3-(chloromethyl)pyridazine hydrochloride

Refernces

• 1、 Hammoud, Ahmad,Nshimyumuremyi, Jean-Boris,Bourotte, Jérémie,Lucaccioni, Fabio,Robeyns, Koen,D?rtu, Marinela M.,Garcia, Yann,Singleton, Michael L.. "Cooperative Interactions in the Second Coordination Sphere of Pyridazine/Pyridine Containing Polyazaheterocyclic Iron(II) Complexes Favor Protonation". . p. 3253 - 3263. Retrieved 2018.
• 2、 Zhang, Yingqian,Zhou, Xiaoping,Xie, Yonghui,Greenberg, Marc M.,Xi, Zhen,Zhou, Chuanzheng. "Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones". . p. 6146 - 6151. Retrieved 2017.