4,8-Decadienoic acid, 2-acetyl-5,9-dimethyl-, ethyl ester, (E)-

Base Information

• Chemical Name: 4,8-Decadienoic acid, 2-acetyl-5,9-dimethyl-, ethyl ester, (E)-
• CAS No.: 19894-78-1
• Molecular Formula: C16H26 O3
• Molecular Weight: 266.381
• Mol file: 19894-78-1.mol

Synonyms:4,8-Decadienoicacid, 2-acetyl-5,9-dimethyl-, ethyl ester, (-)- (8CI); 4,8-Decadienoic acid,2-acetyl-5,9-dimethyl-, ethyl ester, (E)-

Chemical Property of 4,8-Decadienoic acid, 2-acetyl-5,9-dimethyl-, ethyl ester, (E)-

Chemical Property:

• PSA: 43.37000
• LogP: 3.83750

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,8-Decadienoic acid, 2-acetyl-5,9-dimethyl-, ethyl ester, (E)-

There total 1 articles about 4,8-Decadienoic acid, 2-acetyl-5,9-dimethyl-, ethyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl acetoacetate (141-97-9) + 1-chloro-3,7-dimethylocta-2,6-diene (5389-87-7) → (E)-2-acetyl-5,9-dimethyldeca-4,8-dienoic acid ethyl ester (19894-78-1)

Guidance literature:

DOI:10.1055/s-2007-967996

Reference yield: 95.0%

(E)-2-acetyl-5,9-dimethyldeca-4,8-dienoic acid ethyl ester (19894-78-1) → trans geranyl acetone (3796-70-1)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 3h; Reflux;

DOI:10.1055/s-0032-1317528

Reference yield:

(E)-2-acetyl-5,9-dimethyldeca-4,8-dienoic acid ethyl ester (19894-78-1) → cis-nerolidol (3790-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; methanol / 80 °C / Inert atmosphere

2: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With methanol; potassium hydroxide; In tetrahydrofuran;

DOI:10.1002/anie.201906753

upstream raw materials:

ethyl acetoacetate

1-chloro-3,7-dimethylocta-2,6-diene

Downstream raw materials:

trans geranyl acetone

grifolin

1,3-Bis-methoxymethoxy-5-methyl-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-benzene

(E)-2-(2,6-Bis-methoxymethoxy-4-methyl-benzyl)-3-hydroxy-3,7,11-trimethyl-dodeca-6,10-dienoic acid

Refernces

• 1、 Kryshtal,Zhdankina,Zlotin. "Synthesis of derivatives of prenylacetic acids by reactions of alkyl malonate, cyanoacetate, and acetoacetate with alkylating reagents in ionic liquids". . p. 652 - 658. Retrieved 2007/10/03.