Technology Process of 1,3-Bis-methoxymethoxy-5-methyl-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-benzene
There total 10 articles about 1,3-Bis-methoxymethoxy-5-methyl-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-benzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) sodium hydride / 1.) rt, 30 min, DMF; 2.) 40-50 deg C
2: aq. NaOH / 1.) rt, 2 h; 60 deg C, overnight
3: benzene / 1 h / Heating
4: 1.) lithium diisopropylamide / 1.) THF, 40-45 deg C, 2.5 h; -78 deg C, 10 min
5: 1.) EEDQ / 1.) rt, benzene; 2.) toluene, reflux, 5 h
With
sodium hydride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; lithium diisopropyl amide;
In
sodium hydroxide; benzene;
DOI:10.1248/cpb.36.2239
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 83 percent / sodium hydride / dimethylformamide / Ambient temperature
2: 1.) n-butyllithium / 1.) ether, 40 deg C, 1 h; 2.) rt, overnight
3: 84.3 percent / piperidine, pyridine / 90 °C
4: 87 percent / H2 / Pd-C / ethyl acetate / 2 h
5: 1.) lithium diisopropylamide / 1.) THF, 40-45 deg C, 2.5 h; -78 deg C, 10 min
6: 1.) EEDQ / 1.) rt, benzene; 2.) toluene, reflux, 5 h
With
piperidine; pyridine; n-butyllithium; hydrogen; sodium hydride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; lithium diisopropyl amide;
palladium on activated charcoal;
In
ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.2239
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) n-butyllithium / 1.) ether, 40 deg C, 1 h; 2.) rt, overnight
2: 84.3 percent / piperidine, pyridine / 90 °C
3: 87 percent / H2 / Pd-C / ethyl acetate / 2 h
4: 1.) lithium diisopropylamide / 1.) THF, 40-45 deg C, 2.5 h; -78 deg C, 10 min
5: 1.) EEDQ / 1.) rt, benzene; 2.) toluene, reflux, 5 h
With
piperidine; pyridine; n-butyllithium; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; lithium diisopropyl amide;
palladium on activated charcoal;
In
ethyl acetate;
DOI:10.1248/cpb.36.2239