N-dodecyl-4-methoxybenzamide

Base Information

• Chemical Name: N-dodecyl-4-methoxybenzamide
• CAS No.: 1854-15-5
• Molecular Formula: C₂₀H₃₃NO₂
• Molecular Weight: 319.488
• European Community (EC) Number: 442-340-6
• DSSTox Substance ID: DTXSID501309682
• Nikkaji Number: J1.908.455H
• Mol file: 1854-15-5.mol

Synonyms:N-dodecyl-4-methoxybenzamide;1854-15-5;Benzamide, N-dodecyl-4-methoxy-;EC 442-340-6;SCHEMBL4728815;DTXSID501309682;AKOS003871341

Chemical Property of N-dodecyl-4-methoxybenzamide

Chemical Property:

• Boiling Point: 462.7±28.0 °C(Predicted)
• Density: 0.952±0.06 g/cm3(Predicted)
• XLogP3: 5.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 13
• Exact Mass: 319.251129295
• Heavy Atom Count: 23
• Complexity: 285

Purity/Quality:

99.9% ^*data from raw suppliers

N-DODECYL-4-METHOXYBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCCCCCCCCCCCNC(=O)C1=CC=C(C=C1)OC

Technology Process of N-dodecyl-4-methoxybenzamide

There total 6 articles about N-dodecyl-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

n-Dodecylamine (124-22-1) + para-iodoanisole (696-62-8) + ammonium formate (16712-16-6,64165-14-6,65387-22-6,70179-79-2,540-69-2) → N-dodecyl-4-methoxybenzamide (1854-15-5)

Guidance literature:

With sulfuric acid; triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; at 45 ℃; for 24h;

DOI:10.1016/j.jfluchem.2018.10.006

Reference yield: 73.0%

n-Dodecylamine (124-22-1) + 4-methoxybenzoic acid (100-09-4) → N-dodecyl-4-methoxybenzamide (1854-15-5)

Guidance literature:

With 1,3-diazabicyclo[5.4.0]-undec-7-ene; 5-hydro-3-oxaoctafluoropentanesulfonyl fluoride; In dichloromethane; at 20 ℃; for 37h; Reflux;

DOI:10.1016/j.tetlet.2009.03.102

Reference yield:

n-Dodecylamine (124-22-1) + p-nitrophenyl p-methoxybenzoate (7464-46-2) + dodecylamine propionate (17448-65-6) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + N-dodecyl-4-methoxybenzamide (1854-15-5)

Guidance literature:

In cyclohexane; at 30 ℃; Rate constant;

DOI:10.1021/jo00195a039

upstream raw materials:

n-Dodecylamine

4-methoxybenzoic acid

p-nitrophenyl p-methoxybenzoate

dodecylamine propionate

Refernces

• 1、 Adachi, Yusuke,Matsubara, Hiroshi. "Application of phase-vanishing method with CO gas evolution to carbonylation reactions". . p. 89 - 95. Retrieved 2018/10/26.
• 2、 Yan, Zhaohua,Tian, Weisheng,Zeng, Fanrong,Dai, Yanfeng. "5H-3-oxa-Octafluoropentanesulfonyl fluoride: a novel and efficient condensing agent for esterification, amidation and anhydridization". experimental part. p. 2727 - 2729. Retrieved 2009/09/06.