1-chloro-2-(nitromethyl)benzene

Base Information

• Chemical Name: 1-chloro-2-(nitromethyl)benzene
• CAS No.: 79101-70-5
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.583
• Mol file: 79101-70-5.mol

Synonyms:1-chloro-2-(nitromethyl)benzene

Chemical Property of 1-chloro-2-(nitromethyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-chloro-2-(nitromethyl)benzene

There total 3 articles about 1-chloro-2-(nitromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

nitromethane (75-52-5) + 2-bromo-1-chlorobenzene (694-80-4) → 1-chloro-2-(nitromethyl)benzene (79101-70-5)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; at 50 ℃; for 12h; Inert atmosphere; Molecular sieve; Neat (no solvent);

DOI:10.1021/ol301713j

Reference yield:

2-Chlorophenylacetonitrile (2856-63-5) → 1-chloro-2-(nitromethyl)benzene (79101-70-5)

Guidance literature:

With tetrahydrofuran; 1-cyano-1-methylethylnitrate; sodium hydride; aufeinanderfolgendes Behandeln des Reaktionsprodukts mit wss. Natronlauge und mit wss. Salzsaeure;

DOI:10.1021/ja01621a059

Reference yield:

ethyl nitrate (625-58-1) + 2-Chlorophenylacetonitrile (2856-63-5) → 1-chloro-2-(nitromethyl)benzene (79101-70-5)

Guidance literature:

With potassium ethoxide; Kochen des Reaktionsprodukts mit wss. NaOH und anschliessendes Ansaeuern mit wss. HCl;

DOI:10.1039/jr9380001024

upstream raw materials:

ethyl nitrate

2-Chlorophenylacetonitrile

nitromethane

2-bromo-1-chlorobenzene

Downstream raw materials:

2-(2-chloro-β-nitro-styryl)-furan

2,2'-Dichlor-α-nitro-stilben

2-Chlor-α-nitro-stilben

2,2',4'-Trichlor-α-nitro-stilben

Refernces