Technology Process of (6-tert-butyl-5-methoxy-2-methyl-4-phenyl-1H-inden-1-yl)[4-(4-tert-butylphenyl)-2-methyl-1H-inden-1-yl] dimethylsilane
There total 9 articles about (6-tert-butyl-5-methoxy-2-methyl-4-phenyl-1H-inden-1-yl)[4-(4-tert-butylphenyl)-2-methyl-1H-inden-1-yl] dimethylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-(4-tert-butylphenyl)-2-methyl-1H-indene;
With
n-butyllithium;
In
diethyl ether; hexane;
at -78 - 20 ℃;
for 1h;
With
copper(l) cyanide;
In
diethyl ether;
at 20 ℃;
(6-tert-butyl-5-methoxy-2-methyl-4-phenyl-1H-inden-1-yl)(chloro)dimethylsilane;
In
diethyl ether;
at -70 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: Eaton′s Reagent / 2 h / 50 - 55 °C / Cooling with ice
2.1: sodium acetate trihydrate; tetraethylammonium iodide; bromine / dichloromethane; water / 1.08 h / 5 °C
3.1: sodium carbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 12 h / Reflux
4.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 5 °C
5.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 16 h / -20 - 60 °C
5.2: 1 h / 60 °C
6.1: n-butyllithium / hexane; diethyl ether / 1 h / -78 - 20 °C
6.2: 20 °C
6.3: -70 °C
With
sodium tetrahydroborate; n-butyllithium; Eaton′s Reagent; tetraethylammonium iodide; bromine; palladium diacetate; sodium acetate trihydrate; sodium carbonate; triphenylphosphine;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; hexane; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium acetate trihydrate; tetraethylammonium iodide; bromine / dichloromethane; water / 1.08 h / 5 °C
2.1: sodium carbonate; palladium diacetate; triphenylphosphine / water; 1,2-dimethoxyethane / 12 h / Reflux
3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 5 °C
4.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 16 h / -20 - 60 °C
4.2: 1 h / 60 °C
5.1: n-butyllithium / hexane; diethyl ether / 1 h / -78 - 20 °C
5.2: 20 °C
5.3: -70 °C
With
sodium tetrahydroborate; n-butyllithium; tetraethylammonium iodide; bromine; palladium diacetate; sodium acetate trihydrate; sodium carbonate; triphenylphosphine;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; hexane; dichloromethane; water; toluene;
