2,6-Dimethylisonicotinaldehyde

Base Information

• Chemical Name: 2,6-Dimethylisonicotinaldehyde
• CAS No.: 18206-06-9
• Molecular Formula: C8H9NO
• Molecular Weight: 135.166
• Hs Code.: 2933399090
• European Community (EC) Number: 855-219-1
• DSSTox Substance ID: DTXSID40376655
• Wikidata: Q72471837
• Mol file: 18206-06-9.mol

Synonyms:2,6-Dimethylisonicotinaldehyde;18206-06-9;2,6-dimethylpyridine-4-carbaldehyde;2,6-Dimethylpyridine-4-carboxaldehyde;2,6-dimethyl-4-pyridinecarboxaldehyde;MFCD06410687;SCHEMBL378339;AMY8049;DTXSID40376655;OFIMNDTVWZPKIN-UHFFFAOYSA-N;2,6-dimethyl4-pyridinecarboxaldehyde;2,6-dimethyl-pyridine-4-carbaldehyde;AKOS006294576;AB24839;4-Pyridinecarboxaldehyde, 2,6-dimethyl-;AC-33274;DS-11224;SY068152;CS-0089807;FT-0645942;EN300-101676;A812649;Z1198168757

Chemical Property of 2,6-Dimethylisonicotinaldehyde

Chemical Property:

• Vapor Pressure: 0.128mmHg at 25°C
• Melting Point: 8℃
• Refractive Index: 1.5282
• Boiling Point: 218.1 °C at 760 mmHg
• Flash Point: 90.5 °C
• PSA: 29.96000
• Density: 1.065 g/cm³
• LogP: 1.51090
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 135.068413911
• Heavy Atom Count: 10
• Complexity: 114

Purity/Quality:

98%min ^*data from raw suppliers

2,6-Dimethylisonicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=N1)C)C=O

Technology Process of 2,6-Dimethylisonicotinaldehyde

There total 8 articles about 2,6-Dimethylisonicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,6-dimethyl-4-pyridinemethanol (18088-01-2) → 2,6-dimethyl-4-pyridine carboxaldehyde (18206-06-9)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In acetonitrile; for 6h; Concentration; Reagent/catalyst; Reflux;

Reference yield: 82.0%

4-hydroxym-ethyl-2,6-dimethylpyridine + dimethyl sulfoxide (67-68-5,8070-53-9) → 2,6-dimethyl-4-pyridine carboxaldehyde (18206-06-9)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 2h;

Reference yield:

2,6-lutidine N-oxide (1073-23-0) → 2,6-dimethyl-4-pyridine carboxaldehyde (18206-06-9)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 3 h / 20 °C / Inert atmosphere

2: ammonium persulfate / water / 16 h / Inert atmosphere; Reflux

3: manganese(IV) oxide / ethanol / 17 h / Reflux

With manganese(IV) oxide; ammonium persulfate; In ethanol; dichloromethane; water;

upstream raw materials:

2,4,6-trimethyl-pyridine

2,6-lutidine N-oxide

2,6-dimethyl-4-pyridinemethanol

2,6-dimethylpyridine

Downstream raw materials:

methyl 2,6-dimethylpyridine-4-carboxylate

2-(2,6-dimethylpyridin-4-yl)-7-fluoro-5-(2-phenoxyethoxy)-3H-quinazolin-4-one

2-(2,6-dimethylpyridin-4-yl)-7-methoxy-5-(2-phenoxyethoxy)quinazolin-4(3H)-one

7-(2-(benzyloxy)ethoxy)-2-(2,6-dimethylpyridin-4-yl)-5-methoxyquinazolin-4(3H)-one

Refernces

• 1、 Erbas-Cakmak, Sundus,Cakmak, Fatma Pir,Topel, Seda Demirel,Uyar, Taha Bilal,Akkaya, Engin U.. "Selective photosensitization through an and logic response: Optimization of the pH and glutathione response of activatable photosensitizers". . p. 12258 - 12261. Retrieved 2015/07/27.
• 2、 Leitis, L. Ya.,Skolmeistere, R. A.,Golender, L. O.,Yansone, D. P.,Meksh, P. A.,Shimanskaya, M. V.. "REACTIVITY OF METHYL DERIVATIVES OF NITROGENOUS HETEROCYCLES IN VAPOR-PHASE CATALYTIC OXIDATION". . p. 63 - 66. Retrieved 2007/10/02.