Technology Process of 2-(2,6-dimethylpyridin-4-yl)-7-fluoro-5-(2-phenoxyethoxy)-3H-quinazolin-4-one
There total 7 articles about 2-(2,6-dimethylpyridin-4-yl)-7-fluoro-5-(2-phenoxyethoxy)-3H-quinazolin-4-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-Phenoxyethanol;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 1h;
2-(2,6-dimethyl-pyridin-4-yl)-5,7-difluoro-3H-quinazolin-4-one;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dichloromethane / 3 h / 20 °C / Inert atmosphere
2.1: ammonium persulfate / water / 16 h / Inert atmosphere; Reflux
3.1: manganese(IV) oxide / ethanol / 17 h / Reflux
4.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 115 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
5.2: 16 h / 20 °C
With
manganese(IV) oxide; ammonium persulfate; sodium hydride; toluene-4-sulfonic acid; sodium hydrogensulfite;
In
ethanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 115 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
2.2: 16 h / 20 °C
With
sodium hydride; toluene-4-sulfonic acid; sodium hydrogensulfite;
In
N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;