Methyl 4-Methoxy-3,5-diMethylpicolinate

Base Information

• Chemical Name: Methyl 4-Methoxy-3,5-diMethylpicolinate
• CAS No.: 187222-18-0
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Mol file: 187222-18-0.mol

Synonyms:2-methoxycarbonyl-3,5-dimethyl-4-methoxypyridine

Chemical Property of Methyl 4-Methoxy-3,5-diMethylpicolinate

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl4-methoxy-3,5-dimethylpicolinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-Methoxy-3,5-diMethylpicolinate

There total 9 articles about Methyl 4-Methoxy-3,5-diMethylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methanol (67-56-1) + 4-Chloro-2-ethoxycarbonyl-3,5-Lutidine (187222-17-9) → 2-methoxycarbonyl-3,5-dimethyl-4-methoxypyridine (187222-18-0)

Guidance literature:

With sodium methylate; In methanol; for 5h; Heating;

DOI:10.3987/COM-96-7617

Reference yield: 80.0%

→ 2-methoxycarbonyl-3,5-dimethyl-4-methoxypyridine (187222-18-0)

Guidance literature:

Reference yield: 65.0%

2-carboxy-4-hydroxy-3,5-lutidine (447461-21-4) → 2-methoxycarbonyl-3,5-dimethyl-4-methoxypyridine (187222-18-0)

Guidance literature:

In N-methyl-acetamide; water;

upstream raw materials:

methanol

4-Chloro-2-ethoxycarbonyl-3,5-Lutidine

1-hydroxy-2-methyl-1-penten-3-one

1-ethoxy-2-methylpent-1-en-3-one

Downstream raw materials:

(4-methoxy-3,5-dimethylpyridin-2-yl)methanol

Refernces

• 1、 Chou, Shan-Yen,Chen, Shyh-Fong. "Synthesis of 2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine : A key intermediate for omeprazole". . p. 77 - 85. Retrieved 2007/10/03.