ethyl 3,3,3-trifluoro-2-phenylpropionate

Base Information

• Chemical Name: ethyl 3,3,3-trifluoro-2-phenylpropionate
• CAS No.: 90784-42-2
• Molecular Formula: C₁₁H₁₁F₃O₂
• Molecular Weight: 232.202
• Mol file: 90784-42-2.mol

Synonyms:ethyl 3,3,3-trifluoro-2-phenylpropionate

Chemical Property of ethyl 3,3,3-trifluoro-2-phenylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3,3,3-trifluoro-2-phenylpropionate

There total 24 articles about ethyl 3,3,3-trifluoro-2-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl 2-phenyldiazoacetate (22065-57-2) + (trifluoromethyl)trimethylsilane (81290-20-2) → ethyl 3,3,3-trifluoro-2-phenylpropionate (90784-42-2)

Guidance literature:

(trifluoromethyl)trimethylsilane; With copper(l) iodide; cesium fluoride; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

ethyl 2-phenyldiazoacetate; With copper(l) iodide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; at 20 ℃; for 9h; Inert atmosphere;

DOI:10.1021/ja307058c

Reference yield: 77.0%

ethyl 2-deutero-3,3,3-trifluoro-2-phenylpropanoate → ethyl 3,3,3-trifluoro-2-phenylpropionate (90784-42-2)

Guidance literature:

With copper(l) iodide; water; (trifluoromethyl)trimethylsilane; cesium fluoride; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; at 20 ℃; for 20h; Glovebox; Schlenk technique; Inert atmosphere;

DOI:10.1002/cjoc.201600004

Reference yield: 75.0%

Ethyl α-mesyloxy-α-(trifluoromethyl)phenylacetate (175401-23-7) → ethyl 3,3,3-trifluoro-2-phenylpropionate (90784-42-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/0022-1139(95)03338-6

upstream raw materials:

diethyl α-bromodifluoromethyl-α-phenylmalonate

Umemoto's reagent

Ethyl 2-phenylethanoate

Ethyl α-mesyloxy-α-(trifluoromethyl)phenylacetate

Downstream raw materials:

α-(trifluoromethyl)-phenylacetic acid

2-Phenyl-2-trifluormethyl-ethanol

Refernces

• 1、 Ma, Qiao,Tsui, Gavin Chit,Wang, Yanhui. "Stereoselective Palladium-Catalyzed C?F Bond Alkynylation of Tetrasubstituted gem-Difluoroalkenes". supporting information. p. 11293 - 11297. Retrieved 2020/05/25.
• 2、 Pramanik, Suman,Rej, Supriya,Kando, Shun,Tsurugi, Hayato,Mashima, Kazushi. "Organosilicon Reducing Reagents for Stereoselective Formations of Silyl Enol Ethers from α-Halo Carbonyl Compounds". . p. 2409 - 2417. Retrieved 2018/02/23.