MONOMETHYL MALONATE

Base Information

• Chemical Name: MONOMETHYL MALONATE
• CAS No.: 16695-14-0
• Molecular Formula: C4H6O4
• Molecular Weight: 118.089
• Hs Code.: 29161900
• Mol file: 16695-14-0.mol

Synonyms:Methyl malonate;Monomethyl malonate;Propanedioicacid, monomethyl ester (9CI);(Methoxycarbonyl)acetic acid;3-Methoxy-3-oxopropanoic acid;Hydrogen methyl malonate;Methyl hydrogenmalonate;Malonic acid, monomethyl ester (8CI);Malonicacid, methyl ester (6CI);

Chemical Property of MONOMETHYL MALONATE

Chemical Property:

• Refractive Index: 1.428
• Boiling Point: 232.1 °C at 760 mmHg
• PKA: 2.83±0.32(Predicted)
• Flash Point: 103.7 °C
• PSA: 63.60000
• Density: 1.274 g/cm³
• LogP: -0.36590
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

Propanedioic acid 1-methyl ester ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Lactonization of olefins with monomethyl ester of malonic acid and ceric ammonium nitrate was carried out in acetic acid and in acetonitrile under simple mechanical stirring or ultrasound irradiation. Lactonization of olefins with CAN and monomethyl ester of malonic acid under ultrasound irradiation shows an acceleration with respect to the analogous mechanically stirred reaction.

Technology Process of MONOMETHYL MALONATE

There total 15 articles about MONOMETHYL MALONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) + malonic acid (141-82-2) → Malonic acid monomethyl ester (16695-14-0)

Guidance literature:

With Bronsted acidic, ionic liquid containing, heteropolyanion functionalized polysiloxane network POS-HPA-IL; for 1.75h; chemoselective reaction; Reflux; Green chemistry;

DOI:10.1039/d0gc01354d

Reference yield: 84.0%

malonic acid dimethyl ester (108-59-8) → Malonic acid monomethyl ester (16695-14-0)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1016/j.tetlet.2008.05.007

Reference yield: 81.0%

malonic acid dimethyl ester (108-59-8) → malonic acid (141-82-2) + Malonic acid monomethyl ester (16695-14-0)

Guidance literature:

malonic acid dimethyl ester; With potassium hydroxide; water; In acetonitrile; at 0 ℃; for 1h;

With hydrogenchloride; water; In acetonitrile; Product distribution / selectivity;

upstream raw materials:

methanol

malonic acid

malonic acid dimethyl ester

diethyl malonate

Downstream raw materials:

3-(3-nitrophenyl)acrylic acid methyl ester

methyl 3-nitrocinnamate

methyl 4-hydroxycinnamate

3-(4'-dimethylaminophenyl)-(E)-propenoic acid methyl ester

Refernces

• 1、 Grakauskas,V.,Guest,A.M.. "-". . p. 3485 - 3488. Retrieved 1978.
• 2、 Dell’Acqua, Andrea,Wille, Lukas,Stadler, Bernhard M.,Tin, Sergey,de Vries, Johannes G.. "Ozonolysis of α-angelica lactone: a renewable route to malonates". supporting information. p. 10524 - 10527. Retrieved 2021/10/19.
• 3、 Rajabi, Fatemeh,Wilhelm, Christian,Thiel, Werner R.. "A Br?nsted acidic, ionic liquid containing, heteropolyacid functionalized polysiloxane network as a highly selective catalyst for the esterification of dicarboxylic acids". supporting information. p. 4438 - 4444. Retrieved 2020/08/10.