N-L-tyrosyl-L-leucine benzyl ester; hydrochloride

Base Information

• Chemical Name: N-L-tyrosyl-L-leucine benzyl ester; hydrochloride
• CAS No.: 114658-52-5
• Molecular Formula: C₂₂H₂₈N₂O₄*ClH
• Molecular Weight: 420.936
• Mol file: 114658-52-5.mol

Synonyms:N-L-tyrosyl-L-leucine benzyl ester; hydrochloride

Chemical Property of N-L-tyrosyl-L-leucine benzyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-L-tyrosyl-L-leucine benzyl ester; hydrochloride

There total 3 articles about N-L-tyrosyl-L-leucine benzyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-formyl-L-tyrosine (13200-86-7) → N-L-tyrosyl-L-leucine benzyl ester; hydrochloride (114658-52-5)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous NaOH

2: benzoyl chloride; 1-ethyl-piperidine; THF / anschliessend Behandeln mit L-Leucin-benzylester in Aethylacetat und wss. KHCO₃

3: benzyl alcohol

With tetrahydrofuran; 1-ethyl-piperidine; sodium hydroxide; benzoyl chloride; benzyl alcohol;

Reference yield:

O-acetyl-N-formyl-L-tyrosine → N-L-tyrosyl-L-leucine benzyl ester; hydrochloride (114658-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: benzoyl chloride; 1-ethyl-piperidine; THF / anschliessend Behandeln mit L-Leucin-benzylester in Aethylacetat und wss. KHCO₃

2: benzyl alcohol

With tetrahydrofuran; 1-ethyl-piperidine; benzoyl chloride; benzyl alcohol;

Reference yield:

N-(O-acetyl-N-formyl-L-tyrosyl)-L-leucine benzyl ester + acetyl chloride (75-36-5) → N-L-tyrosyl-L-leucine benzyl ester; hydrochloride (114658-52-5)

Guidance literature:

With benzyl alcohol;

upstream raw materials:

acetyl chloride

N-formyl-L-tyrosine

Downstream raw materials:

Ac-Ala-Tyr-Leu-Val-CH₂Cl

Ac-Ala-Tyr-Leu-OH

Boc-Glu(O^tBu)-Tyr[CO(CH₂)4CO-bzoc⁶A(=CMe₂)]-Leu-morpholine

C₅₆H₇₀N₈O₁₆S