1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE

Base Information

• Chemical Name: 1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE
• CAS No.: 15183-74-1
• Molecular Formula: C8H7 F3 O3 S
• Molecular Weight: 240.203
• Hs Code.: 2909309090
• Mol file: 15183-74-1.mol

Synonyms:Anisole,p-[(trifluoromethyl)sulfonyl]- (8CI)

Chemical Property of 1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE

Chemical Property:

• PSA: 51.75000
• LogP: 3.06950

Purity/Quality:

1-Methoxy-4-((trifluoromethyl)sulfonyl)benzene 97% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE

There total 17 articles about 1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxybenzene-1-sulfonyl fluoride (368-91-2) + (trifluoromethyl)trimethylsilane (81290-20-2) → 1-methoxy-4-((trifluoromethyl)sulfonyl)benzene (15183-74-1)

Guidance literature:

With potassium hydrogen difluoride; In dimethyl sulfoxide; at 20 ℃; for 1h;

DOI:10.1002/anie.201813761

Reference yield: 89.0%

Langlois reagent (2926-29-6) + bis(4-anisyl)iodonium triflate (141339-54-0) → 1-methoxy-4-((trifluoromethyl)sulfonyl)benzene (15183-74-1)

Guidance literature:

With copper(I) oxide; In N,N-dimethyl-formamide; at 20 ℃; for 72h; Inert atmosphere;

Reference yield: 88.0%

(4-methoxyphenyl)(mesityl)iodonium trifluoromethanesulfonate (1330681-27-0) + Langlois reagent (2926-29-6) → 1-methoxy-4-((trifluoromethyl)sulfonyl)benzene (15183-74-1)

Guidance literature:

With copper(I) oxide; In N,N-dimethyl-formamide; at 20 ℃; for 72h; Inert atmosphere;

upstream raw materials:

trifluoromethylsulfonic anhydride

4-methoxyphenyl magnesium bromide

4-(trifluoromethylsulfonyl)chlorobenzene

sodium methylate

Downstream raw materials:

2-nitro-4-((trifluoromethyl)sulfonyl)anisole

2,6-dinitro-4-((trifluoromethyl)sulfonyl)anisole

2-chlorobenzamide

4-methoxylbiphenyl

Refernces

• 1、 Liu, Yongan,Yu, Donghai,Guo, Yong,Xiao, Ji-Chang,Chen, Qing-Yun,Liu, Chao. "Arenesulfonyl Fluoride Synthesis via Copper-Catalyzed Fluorosulfonylation of Arenediazonium Salts". supporting information. p. 2281 - 2286. Retrieved 2020/03/13.
• 2、 Fukuda, Jun-Ichi,Nogi, Keisuke,Yorimitsu, Hideki. "Cross-Coupling of Aryl Trifluoromethyl Sulfones with Arylboronates by Cooperative Palladium/Rhodium Catalysis". supporting information. p. 8987 - 8991. Retrieved 2019/11/11.