N,N-dimethyl-2-(trimethylsilyl)aniline

Base Information

• Chemical Name: N,N-dimethyl-2-(trimethylsilyl)aniline
• CAS No.: 17961-92-1
• Molecular Formula: C₁₁H₁₉NSi
• Molecular Weight: 193.364
• Mol file: 17961-92-1.mol

Synonyms:N,N-dimethyl-2-(trimethylsilyl)aniline

Chemical Property of N,N-dimethyl-2-(trimethylsilyl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dimethyl-2-(trimethylsilyl)aniline

There total 5 articles about N,N-dimethyl-2-(trimethylsilyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

chloro-trimethyl-silane (75-77-4) + 2-bromo-N,N-dimethylaniline (698-00-0) → N,N-dimethyl-2-(trimethylsilyl)aniline (17961-92-1)

Guidance literature:

2-bromo-N,N-dimethylaniline; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

DOI:10.1021/acs.orglett.1c02280

Reference yield: 72.0%

chloro-trimethyl-silane (75-77-4) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → N,N-dimethyl-2-(trimethylsilyl)aniline (17961-92-1)

Guidance literature:

N,N-dimethyl-aniline; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In hexane; at 72 ℃; for 48h; Inert atmosphere; Sealed tube;

chloro-trimethyl-silane; In hexane; at -20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.jorganchem.2019.121068

Reference yield: 50.0%

chloro-trimethyl-silane (75-77-4) + ortho-lithio-N,N-dimethylaniline (22608-37-3) → N,N-dimethyl-2-(trimethylsilyl)aniline (17961-92-1)

Guidance literature:

In not given; (CH3)3SiCl and LiC6H4N(CH3)2; hydrolysis;;

DOI:10.1021/ja01174a049 DOI:10.1021/jo01152a013

upstream raw materials:

chloro-trimethyl-silane

2-bromo-N,N-dimethylaniline

ortho-lithio-N,N-dimethylaniline

N,N-dimethyl-aniline

Downstream raw materials:

N,N-dimethyl-aniline

Refernces

• 1、 Antonov, Alexander S.,Bardakov, Victor G.,Mulloyarova, Valeriia V.. "Sterically facilitated meta-lithiation of arenes, containing electron-donating groups". . . Retrieved 2020.