(E)-1-(4-methoxyphenyl)ethan-1-one O-methyl oxime

Base Information

• Chemical Name: (E)-1-(4-methoxyphenyl)ethan-1-one O-methyl oxime
• CAS No.: 80965-21-5
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Mol file: 80965-21-5.mol

Synonyms:(E)-1-(4-methoxyphenyl)ethan-1-one O-methyl oxime

Chemical Property of (E)-1-(4-methoxyphenyl)ethan-1-one O-methyl oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-1-(4-methoxyphenyl)ethan-1-one O-methyl oxime

There total 5 articles about (E)-1-(4-methoxyphenyl)ethan-1-one O-methyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-methoxylamine hydrochloride (593-56-6) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 1-(4-Methoxy-phenyl)-ethanone O-methyl-oxime (72278-08-1,80965-21-5,80965-23-7)

Guidance literature:

With sodium acetate; In ethanol; water; for 2h; Reflux;

Reference yield: 80.0%

(E)-1-(4-methoxyphenyl)ethanone oxime (2475-92-5) + methyl iodide (74-88-4) → (E)-1-(4-methoxyphenyl)ethan-1-one O-methyl oxime (80965-21-5)

Guidance literature:

(E)-1-(4-methoxyphenyl)ethanone oxime; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h;

DOI:10.1021/jo060123n

Reference yield:

(E)-1-(4-methoxyphenyl)ethanone oxime (2475-92-5) + methyl iodide (74-88-4) → (E)-1-(4-methoxyphenyl)ethan-1-one O-methyl oxime (80965-21-5) + 1-(4-methoxyphenyl)ethanone (100-06-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 30 ℃; for 72h;

DOI:10.1021/jo00349a026

upstream raw materials:

(Z)-p-methoxyacetophenone O-methyloxime

(E)-1-(4-methoxyphenyl)ethanone oxime

methyl iodide

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

4-methoxyacetophenone oxime

(Z)-p-methoxyacetophenone O-methyloxime

1-(4-methoxyphenyl)ethanone

3-Hydroxy-1,3-bis-(4-methoxy-phenyl)-propan-1-one O-methyl-oxime

Refernces

• 1、 Paul, Amrita,Shah, Sk. Sheriff,Shee, Maniklal,Singh, Amit Kumar,Singh, N. D. Pradeep. "Direct Oxygenation of C-H Bonds through Photoredox and Palladium Catalysis". . p. 3426 - 3439. Retrieved 2020/03/23.
• 2、 Gong, Wanchun,Zhou, Zhi,Shi, Jingjing,Wu, Bo,Huang, Biyun,Yi, Wei. "Catalyst-Controlled [3 + 2] and [4 + 2] Annulations of Oximes with Propargyl Alcohols: Divergent Access to Indenamines and Isoquinolines". supporting information. p. 182 - 185. Retrieved 2018/01/17.