2,4,5-trifluorophenylacetic acid methyl ester

Base Information

• Chemical Name: 2,4,5-trifluorophenylacetic acid methyl ester
• CAS No.: 1036273-20-7
• Molecular Formula: C₉H₇F₃O₂
• Molecular Weight: 204.149
• Mol file: 1036273-20-7.mol

Synonyms:2,4,5-trifluorophenylacetic acid methyl ester

Chemical Property of 2,4,5-trifluorophenylacetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,5-trifluorophenylacetic acid methyl ester

There total 4 articles about 2,4,5-trifluorophenylacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,2-dimethoxy-propane (77-76-9) + (2,4,5-trifluorophenyl)acetic acid (209995-38-0) → 2,4,5-trifluorophenylacetic acid methyl ester (1036273-20-7)

Guidance literature:

With chloro-trimethyl-silane; In methanol; at 20 ℃; for 24h;

DOI:10.1080/15257770.2013.838261

Reference yield: 93.0%

methyl 2-(2,4,5-trifluorophenyl)-2-chloroacetate (1036273-12-7) → 2,4,5-trifluorophenylacetic acid methyl ester (1036273-20-7)

Guidance literature:

With iron; acetic acid; at 60 ℃; for 8h; Product distribution / selectivity;

Reference yield:

1-bromo-2,4,5-trifluorobenzene (327-52-6) + bromoacetic acid methyl ester (96-32-2) → 2,4,5-trifluorophenylacetic acid methyl ester (1036273-20-7)

Guidance literature:

1-bromo-2,4,5-trifluorobenzene; With magnesium; In tetrahydrofuran; at 30 ℃;

bromoacetic acid methyl ester; With di-n-propylamine; cobalt(II) chloride; In tetrahydrofuran; at -10 - 30 ℃; for 0.75h;

upstream raw materials:

methyl 2-(2,4,5-trifluorophenyl)-2-chloroacetate

2,2-dimethoxy-propane

(2,4,5-trifluorophenyl)acetic acid

methanol

Downstream raw materials:

(2,4,5-trifluorophenyl)acetic acid

2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine 2-(2,4,5-trifluorophenyl)ethyl ester

2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine2-(2,4,5-trifluorophenyl)ethyl ester

N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine 2-(2,4,5-trifluorophenyl)ethyl ester

Refernces

• 1、 Bao, Longzhu,Wang, Shuangshuang,Song, Di,Wang, Jingjing,Cao, Xiufang,Ke, Shaoyong. "Synthesis and bio-evaluation of natural butenolides-acrylate conjugates". . . Retrieved 2019/04/05.
• 2、 Leszczynska, Grazyna,Leonczak, Piotr,Dziergowska, Agnieszka,Malkiewicz, Andrzej. "Mt-tRNA components: Synthesis of (2-Thio)uridines modified with blocked glycine/taurine moieties at C-5,1". . p. 599 - 616. Retrieved 2013/11/19.