Technology Process of methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate
There total 13 articles about methyl 2-tert-butoxy-2-(4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
perchloric acid;
In
dichloromethane; ethyl acetate;
at 0 - 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 6 h / 100 - 110 °C / Inert atmosphere
2: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 3 h / 10 - 25 °C
3: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere
4: hydrogenchloride / water / 18 h / 100 °C
5: sulfuric acid / 18 h / Reflux
6: perchloric acid / dichloromethane; ethyl acetate / 4 h / 0 - 20 °C
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); perchloric acid; sulfuric acid; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; zinc(II) iodide;
In
dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
1: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere
2: hydrogenchloride / water / 18 h / 100 °C
3: sulfuric acid / 18 h / Reflux
4: perchloric acid / dichloromethane; ethyl acetate / 4 h / 0 - 20 °C
With
hydrogenchloride; perchloric acid; sulfuric acid; zinc(II) iodide;
In
dichloromethane; water; ethyl acetate;