N-(4-methanesulfonylamino-2-sulfamoylphenyl)malonamic acid methyl ester

Base Information

• Chemical Name: N-(4-methanesulfonylamino-2-sulfamoylphenyl)malonamic acid methyl ester
• CAS No.: 1000313-19-8
• Molecular Formula: C₁₁H₁₅N₃O₇S₂
• Molecular Weight: 365.388
• Mol file: 1000313-19-8.mol

Synonyms:N-(4-methanesulfonylamino-2-sulfamoylphenyl)malonamic acid methyl ester

Chemical Property of N-(4-methanesulfonylamino-2-sulfamoylphenyl)malonamic acid methyl ester

Chemical Property:

• Density: 1.599±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methanesulfonylamino-2-sulfamoylphenyl)malonamic acid methyl ester

There total 19 articles about N-(4-methanesulfonylamino-2-sulfamoylphenyl)malonamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

N-(4-amino-2-sulfamoylphenyl)malonamic acid methyl ester (1618673-18-9) + methanesulfonyl chloride (124-63-0) → N-(4-methanesulfonylamino-2-sulfamoylphenyl)malonamic acid methyl ester (1000313-19-8)

Guidance literature:

With pyridine; In acetonitrile; at 20 ℃;

Reference yield: 87.0%

2-amino-5-(methanesulfonylamino)benzenesulfonamide (691361-76-9) + 3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) → N-(4-methanesulfonylamino-2-sulfamoylphenyl)malonamic acid methyl ester (1000313-19-8)

Guidance literature:

3-chloro-3-oxopropanoic acid methyl ester; for 0.166667h;

2-amino-5-(methanesulfonylamino)benzenesulfonamide; In N,N-dimethyl acetamide; at 0 - 25 ℃; for 1h;

Reference yield:

4-chlorobenzonitrile (100-00-5) → N-(4-methanesulfonylamino-2-sulfamoylphenyl)malonamic acid methyl ester (1000313-19-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 h / 120 °C

2: ammonia / water / 18 h / 25 °C

3: ammonia; ammonium carbonate; copper(II) sulfate / water / 4 h / 120 °C

4: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 26 h / 25 °C / 760.05 Torr

5: pyridine / acetonitrile / 15.25 h / 25 °C

6: N,N-dimethyl acetamide / 1 h / 0 - 25 °C

With pyridine; ammonia; hydrogen; ammonium carbonate; copper(II) sulfate; palladium 10% on activated carbon; In tetrahydrofuran; N,N-dimethyl acetamide; water; acetonitrile;

upstream raw materials:

2-amino-5-(methanesulfonylamino)benzenesulfonamide

3-chloro-3-oxopropanoic acid methyl ester

2-chloro-5-nitrobenzenesulfonamide

2,5-diaminobenzenesulfonamide

Downstream raw materials:

N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0(2,7)]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide

(1S,2R,3S,4R)-3-{(4-fluorobenzyl)-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester

N-{3-[(1R,2S,7R,8S)-3-(4-fluorobenzyl)-6-hydroxy-4-oxo-3-azatricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide L-arginine salt

N-{3-[(1R,2S,7R,8S)-3-(4-fluorobenzyl)-6-hydroxy-4-oxo-3-azatricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide L-lysine salt

Refernces

• 1、 -. "A METHOD OF INHIBITING HEPATITIS C VIRUS BY COMBINATION OF A 5,6-DIHYDRO-1H-PYRIDIN-2-ONE AND ONE OR MORE ADDITIONAL ANTIVIRAL COMPOUNDS". Page/Page column 40-41. . Retrieved 2010/04/28.
• 2、 -. "PYRIDAZINONE COMPOUNDS". Page/Page column 171-172. . Retrieved 2008/12/07.