Methyl 3-chloro-3-oxopropionate

Base Information Edit

Chemical Name:Methyl 3-chloro-3-oxopropionate
CAS No.:37517-81-0
Molecular Formula:C4H5ClO3
Molecular Weight:136.535
Hs Code.:29171900
European Community (EC) Number:253-540-6
UNII:UAT3SX9MTD
DSSTox Substance ID:DTXSID40190959
Nikkaji Number:J261.191K
Wikidata:Q72492482
Mol file:37517-81-0.mol

Synonyms:Methyl malonyl chloride;37517-81-0;Methyl 3-chloro-3-oxopropionate;methyl 3-chloro-3-oxopropanoate;Propanoic acid, 3-chloro-3-oxo-, methyl ester;Methyl chloroformylacetate;UAT3SX9MTD;EINECS 253-540-6;MFCD00013657;AI3-51039;Propanoic acid, 3-chloro-2-oxo-, methyl ester;METHYL-3-CHLORO-3-OXOPROPIONATE;UNII-UAT3SX9MTD;methyl chlorocarbonylacetate;carbomethoxy acetyl chloride;Methyl (Chloroformyl)acetate;SCHEMBL31468;methyl3-chloro-3-oxopropanoate;methyl 2-(chlorocarbonyl)acetate;chlorocarbonyl-acetic methyl ester;DTXSID40190959;(Malonic acid 1-methyl) chloride;methyl 3-chloro-3-oxo-propanoate;Methyl-3-chloro-3-oxo-propionate;BCP22276;BBL100053;STL511027;chlorocarbonylacetic acid methyl ester;AKOS000121252;chlorocarbonyl-acetic acid methyl ester;(Chloroformyl)acetic Acid Methyl Ester;AM90205;Methyl 3-chloro-3-oxopropionate, 97%;AS-15907;3-Chloro-3-oxopropionic Acid Methyl Ester;FT-0628750;M2315;EN300-20669;D78113;Methyl malonyl chloride, purum, >=97.0% (AT);A823718;Q-101210

Suppliers and Price of Methyl 3-chloro-3-oxopropionate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Methyl Malonyl Chloride
5g
$ 337.00

TRC
Methyl 3-chloro-3-oxopropionate
10g
$ 90.00

TCI Chemical
Methyl Malonyl Chloride >97.0%(GC)(T)
25g
$ 162.00

TCI Chemical
Methyl Malonyl Chloride >97.0%(GC)(T)
5g
$ 47.00

SynQuest Laboratories
Methyl malonyl chloride 97%
25 g
$ 72.00

SynQuest Laboratories
Methyl malonyl chloride 97%
100 g
$ 208.00

SynQuest Laboratories
Methyl malonyl chloride 97%
250 g
$ 440.00

Sigma-Aldrich
Methyl malonyl chloride purum, ≥97.0% (AT)
50ml
$ 515.00

Sigma-Aldrich
Methyl 3-chloro-3-oxopropionate 97%
25g
$ 193.00

Sigma-Aldrich
Methyl malonyl chloride purum, ≥97.0% (AT)
10ml
$ 149.00

Total 101 raw suppliers

Chemical Property of Methyl 3-chloro-3-oxopropionate Edit

Chemical Property:

Appearance/Colour:Clear light yellow to yellow liquid
Vapor Pressure:1.69mmHg at 25°C
Refractive Index:n20/D 1.432(lit.)
Boiling Point:167.5 °C at 760 mmHg
PKA:9.33±0.46(Predicted)
Flash Point:80 °C
PSA：43.37000
Density:1.281 g/cm³
LogP:0.31490
Storage Temp.:2-8°C
Sensitive.:Lachrymatory
Water Solubility.:Reacts with water.
XLogP3:0.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:135.9927217
Heavy Atom Count:8
Complexity:110

Purity/Quality:

99% ^*data from raw suppliers

Methyl Malonyl Chloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:C
Statements: 34-36/37
Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:COC(=O)CC(=O)Cl
Uses Methyl malonyl chloride is used as pharmaceutical intermediate. Used in anti-cancer drugs.

Technology Process of Methyl 3-chloro-3-oxopropionate

There total 6 articles about Methyl 3-chloro-3-oxopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%