ethyl 2-phenethylbenzoate

Base Information

• Chemical Name: ethyl 2-phenethylbenzoate
• CAS No.: 5505-02-2
• Molecular Formula: C₁₇H₁₈O₂
• Molecular Weight: 254.329
• Mol file: 5505-02-2.mol

Synonyms:ethyl 2-phenethylbenzoate

Chemical Property of ethyl 2-phenethylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of ethyl 2-phenethylbenzoate

There total 6 articles about ethyl 2-phenethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl 2-iodobenzoate (1829-28-3) + phenethylmagnesium chloride (90878-19-6) → ethyl 2-phenethylbenzoate (5505-02-2)

Guidance literature:

phenethylmagnesium chloride; With zinc(II) chloride; In tetrahydrofuran;

ethyl 2-iodobenzoate; With dichloro bis(acetonitrile) palladium(II); diethyl bicyclo[2.2.1]hept-2,5-diene-2,3-dicarboxylate; In tetrahydrofuran; at 60 ℃; for 2h; Inert atmosphere;

DOI:10.1002/adsc.200800118

Reference yield: 98.0%

ethyl 2-iodobenzoate (1829-28-3) + (2-phenylethyl)zinc chloride → ethyl 2-phenethylbenzoate (5505-02-2)

Guidance literature:

With C₁₅H₂₄ClN₃PdS₂⁽¹⁺⁾*Cl^(1-); In tetrahydrofuran; at 25 ℃; Inert atmosphere;

DOI:10.1002/chem.200801860

Reference yield: 96.0%

phenethylmagnesium bromide (3277-89-2) + ethyl 2-iodobenzoate (1829-28-3) → ethyl 2-phenethylbenzoate (5505-02-2)

Guidance literature:

phenethylmagnesium bromide; With zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 1h;

ethyl 2-iodobenzoate; dichloro bis(acetonitrile) palladium(II); In tetrahydrofuran; at 20 ℃; for 2h; Further stages.;

DOI:10.1021/ol701995t

upstream raw materials:

Ethyl 2-(2-phenylethenyl)benzoate

ethanol

phenethylmagnesium bromide

ethyl 2-iodobenzoate

Downstream raw materials:

(E)-N¹,N¹,N⁷,N⁷-Tetramethyl-4-(2-phenethyl-phenyl)-hept-3-ene-1,7-diamine

N,N,N',N'-Tetramethyl-4-(2-phenethyl-phenyl)-heptane-1,7-diamine

1,7-Bis-dimethylamino-4-(2-phenethyl-phenyl)-heptan-4-ol

o-phenethylbenzoic acid

Refernces

• 1、 Liu, Jing,Deng, Yi,Wang, Haibo,Zhang, Hua,Yu, Ganxiang,Wu, Bingbin,Zhang, Heng,Li, Qiang,Marder, Todd B.,Yang, Zhen,Lei, Aiwen. "Effective Pd-nanoparticle (PdNP)-catalyzed negishi coupling involving alkylzinc reagents at room temperature". supporting information; experimental part. p. 2661 - 2664. Retrieved 2009/05/27.
• 2、 Luo, Xiancai,Zhang, Heng,Duan, Hui,Liu, Qiang,Zhu, Lizheng,Zhang, Tony,Lei, Aiwen. "Superior effect of a π-acceptor ligand (phosphine-electron-deficient olefin ligand) in the Negishi coupling involving alkylzinc reagents". . p. 4571 - 4574. Retrieved 2008/03/12.