DIMETHYL PYRAZINE-2,5-DICARBOXYLATE

Base Information

• Chemical Name: DIMETHYL PYRAZINE-2,5-DICARBOXYLATE
• CAS No.: 13051-89-3
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.163
• Hs Code.: 2933990090
• Mol file: 13051-89-3.mol

Synonyms:2,5-Pyrazinedicarboxylicacid, dimethyl ester (6CI,7CI,8CI,9CI); Dimethyl 2,5-pyrazinedicarboxylate

Chemical Property of DIMETHYL PYRAZINE-2,5-DICARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.000563mmHg at 25°C
• Melting Point: 169.5-170.1 °C(Solv: methanol (67-56-1))
• Refractive Index: 1.518
• Boiling Point: 311.4°Cat760mmHg
• PKA: -4.24±0.10(Predicted)
• Flash Point: 142.2°C
• PSA: 78.38000
• Density: 1.293g/cm³
• LogP: 0.04980

Purity/Quality:

98%min ^*data from raw suppliers

DimethylPyrazine-?2,?5-?dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dimethyl Pyrazine-?2,?5-?dicarboxylate is a reactant used in the synthesis of biologically actve agents. It is used in the synthesis of proteasome inhibitors for multiple myeloma, as well as for they synthesis of pyrazinyl and pyridinyl bis(oxazoline) ligands used in the preparation of (R)-Verapamil (V124990).

Technology Process of DIMETHYL PYRAZINE-2,5-DICARBOXYLATE

There total 7 articles about DIMETHYL PYRAZINE-2,5-DICARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + 2,5-pyrazinedicarboxylic acid (122-05-4) → dimethyl Pyrazine-2,5-dicarboxylate (13051-89-3)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/j.bmcl.2013.09.043

Reference yield: 71.0%

N,N-bis-(tert-butoxycarbonyl)-2,5-bis-methoxycarbonyl-1,4-dihydropyrazine (773896-53-0) → dimethyl Pyrazine-2,5-dicarboxylate (13051-89-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tet.2004.06.127

Reference yield:

2,5-pyrazinedicarboxylic acid (122-05-4) → dimethyl Pyrazine-2,5-dicarboxylate (13051-89-3)

Guidance literature:

In methanol; chloroform;

upstream raw materials:

methanol

2,5-pyrazinedicarboxylic acid

2-5-dibromopyrazine

potassium cyanide

Downstream raw materials:

2,5-pyrazinedicarboxylic acid

2,5-piperazinedicarboxylic acid

methyl 5-(bromomethyl)pyrazine-2-carboxylate

methyl 5-(hydroxymethyl)pyrazine-2-carboxylate

Refernces

• 1、 Ellingson,Henry. "-". . p. 2798. Retrieved 1949.
• 2、 -. "TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A PYRIDINE OR PYRAZINE MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR". Paragraph 0137. . Retrieved 2019/02/28.
• 3、 -. "DOPAMINE D3 RECEPTOR ANTAGONISTS COMPOUNDS". Page/Page column 126. . Retrieved 2016/05/19.