Technology Process of N-methyl-3-nitro-4-[(3,3,3-trifluoro-1-methylpropyl)oxy]benzenesuIfonamide
There total 3 articles about N-methyl-3-nitro-4-[(3,3,3-trifluoro-1-methylpropyl)oxy]benzenesuIfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4,4,4-trifluoro-2-butanol;
With
sodium hydride;
In
1,4-dioxane; mineral oil;
at 0 - 20 ℃;
for 0.5h;
Sealed vessel;
4-fluoro-N-methyl-3-nitrobenzenesulfonamide;
In
1,4-dioxane;
at 110 ℃;
for 20h;
Sealed vessel;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / tetrahydrofuran / 1 h / -35 °C
2.1: sodium hydride / 1,4-dioxane; mineral oil / 0.5 h / 0 - 20 °C / Sealed vessel
2.2: 20 h / 110 °C / Sealed vessel
With
sodium hydride; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: chlorosulfonic acid / 18 h / 100 °C
2.1: triethylamine / tetrahydrofuran / 1 h / -35 °C
3.1: sodium hydride / 1,4-dioxane; mineral oil / 0.5 h / 0 - 20 °C / Sealed vessel
3.2: 20 h / 110 °C / Sealed vessel
With
chlorosulfonic acid; sodium hydride; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; mineral oil;
