6-(CHLOROMETHYL)PHENANTHRIDINE

Base Information

• Chemical Name: 6-(CHLOROMETHYL)PHENANTHRIDINE
• CAS No.: 40484-36-4
• Molecular Formula: C14H10ClN
• Molecular Weight: 227.693
• Hs Code.: 2933990090
• Mol file: 40484-36-4.mol

Synonyms:6-(Chloromethyl)phenanthridine;NSC 8011;

Chemical Property of 6-(CHLOROMETHYL)PHENANTHRIDINE

Chemical Property:

• Vapor Pressure: 4.56E-06mmHg at 25°C
• Refractive Index: 1.71
• Boiling Point: 394.2 °C at 760 mmHg
• Flash Point: 224.5 °C
• PSA: 12.89000
• Density: 1.274 g/cm³
• LogP: 4.12680

Purity/Quality:

99% ^*data from raw suppliers

6-(Chloromethyl)phenanthridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(CHLOROMETHYL)PHENANTHRIDINE

There total 6 articles about 6-(CHLOROMETHYL)PHENANTHRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-([1,1'-biphenyl]-2-yl)-2-chloroacetamide (23088-28-0) → 6-(chloromethyl)phenanthridine (40484-36-4)

Guidance literature:

With trifluoromethylsulfonic anhydride; Triphenylphosphine oxide; In dichloromethane; at 0 - 20 ℃; for 5.5h; Inert atmosphere;

DOI:10.102l/Jacs.6bl09B2

Reference yield:

N-chloro-succinimide (128-09-6) + 6-methylphenanthridine (3955-65-5) → 6-(chloromethyl)phenanthridine (40484-36-4)

Guidance literature:

With tetrachloromethane; dibenzoyl peroxide;

DOI:10.1021/ja01145a099

Reference yield:

2-phenylaniline (90-41-5) → 6-(chloromethyl)phenanthridine (40484-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / diethyl ether / 1 h / 0 °C

2: 80 percent / POCl₃ / Heating

With trichlorophosphate; In diethyl ether;

upstream raw materials:

N-chloro-succinimide

6-methylphenanthridine

N-([1,1'-biphenyl]-2-yl)-2-chloroacetamide

2-phenylaniline

Downstream raw materials:

N,N-bis-phenanthridin-6-ylmethyl-toluene-4-sulfonamide

6-(p-tosylamidomethyl)phenanthridine

2-tosyl-1,2,3,12b-tetrahydroimidazol<1,5-f>phenanthridine

C₂₂H₁₉⁽²⁾HN₂O₂S

Refernces

• 1、 Raszeja, Lukasz,Maghnouj, Abdelouahid,Hahn, Stephan,Metzler-Nolte, Nils. "A Novel Organometallic ReI Complex with Favourable Properties for Bioimaging and Applicability in Solid-Phase Peptide Synthesis". scheme or table. p. 371 - 376. Retrieved 2012/01/06.
• 2、 Lion, C.,Boukou-Poba, J. P.,Charvy, C.. "SYNTHESE DANS LA SERIE DES PHENANTHRIDINES I. RECHERCHES DES CONDITIONS EXPERIMENTALES OPTIMALES DANS LA PREPARATION D'ALKYL-6 PHENANTHRIDINES ET DE LEUR SEL". . p. 557 - 566. Retrieved 2007/10/02.