23088-28-0

Basic information

• Product Name: N-2-Biphenylyl-2-chloroacetamide
• Synonyms: N-BIPHENYL-2-YL-2-CHLORO-ACETAMIDE;N-1,1'-BIPHENYL-2-YL-2-CHLOROACETAMIDE;CHEMBRDG-BB 6636578;AKOS BBS-00004046;N-2-Biphenylyl-2-chloroacetamide;2-Chloro-2'-phenylacetanilide;N-[1,1'-Diphenyl]-2-yl-2-chloro-acetaMide;N-Chloroacetyldiphenyl-2-aMine
• CAS NO: 23088-28-0
• Molecular Formula: C₁₄H₁₂ClNO
• Molecular Weight: 245.7
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 23088-28-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 101-103 °C
• Boiling Point: 406.2°C at 760 mmHg
• Flash Point: 199.5°C
• Appearance: /
• Density: 1.233g/cm³
• Vapor Pressure: 8.27E-07mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: 2-8°C
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• PKA: 12.66±0.70(Predicted)
• CAS DataBase Reference: N-2-Biphenylyl-2-chloroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-2-Biphenylyl-2-chloroacetamide(23088-28-0)
• EPA Substance Registry System: N-2-Biphenylyl-2-chloroacetamide(23088-28-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 23088-28-0(Hazardous Substances Data)

Usage

Chemical Properties

N-2-Biphenylyl-2-chloroacetamide is Off-White Solid

Uses

Different sources of media describe the Uses of 23088-28-0 differently. You can refer to the following data:
1. N-2-Biphenylyl-2-chloroacetamide is a reagent used in the production of γ-secretase inhibitors
2. A reagent used in the production of γ-secretase inhibitors

InChI:InChI=1/C14H12ClNO/c15-10-14(17)16-13-9-5-4-8-12(13)11-6-2-1-3-7-11/h1-9H,10H2,(H,16,17)

Upstream product

• 90-41-5 2-phenylaniline 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1271731-41-9 4-[bis(6-phenanthridinylmethyl)aminomethyl]benzoic acid 
• 1271731-46-4 4-[(bis(6-phenanthridinylmethyl)amino)methyl]benzoic acid methyl ester 
• 17613-40-0 bromo-6 phenanthridine 
• 1015-89-0 6(5H)-phenanthridinone 
• 20011-90-9 5H,7H-dibenzo[b,d]azepin-6-one 
• 40484-36-4 6-(chloromethyl)phenanthridine 

Relevant articles and documents

MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO

This disclosure relates to compounds having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such compounds and intermediates used in such processes, compositions containing such compounds, and processes of using such compounds against such pests. These compounds/molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses compounds having the following formula (Formula One and/or Formula One-A).

Discovery of novel N -phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis

In this paper, we describe the screening of a 14640-compound library using a novel whole mycobacteria phenotypic assay to discover inhibitors of EthR, a transcriptional repressor implicated in the innate resistance of Mycobacterium tuberculosis to the second-line antituberculosis drug ethionamide. From this screening a new chemical family of EthR inhibitors bearing an N-phenylphenoxyacetamide motif was identified. The X-ray structure of the most potent compound crystallized with EthR inspired the synthesis of a 960-member focused library. These compounds were tested in vitro using a rapid thermal shift assay on EthR to accelerate the optimization. The best compounds were synthesized on a larger scale and confirmed as potent ethionamide boosters on M. tuberculosis-infected macrophages. Finally, the cocrystallization of the best optimized analogue with EthR revealed an unexpected reorientation of the ligand in the binding pocket.

Improved synthesis of (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one, a building block for γ-secretase inhibitors

An improved synthesis of (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one (1), involving a selective crystallization of epimeric menthylcarbamates for the resolution step followed by simultaneous cleavage of the carbamate and the lactam protecting group is desc