Cyclopropaneoctanoicacid,

Base Information

• Chemical Name: Cyclopropaneoctanoicacid,
• CAS No.: 10152-61-1
• Molecular Formula: C₁₈H₃₄O₂
• Molecular Weight: 282.467
• Hs Code.: 2916209090
• Mol file: 10152-61-1.mol

Synonyms:Methyl9,10-methylenehexadecanoate

Chemical Property of Cyclopropaneoctanoicacid,

Chemical Property:

• Boiling Point: 140 °C(Press: 0.8 Torr)
• PSA: 26.30000
• Density: 0.901±0.06 g/cm3(Predicted)
• LogP: 5.49660

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropaneoctanoicacid,

There total 3 articles about Cyclopropaneoctanoicacid, which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

diiodomethane (75-11-6) + (Z)-9-hexadecenoic acid methyl ester (1120-25-8,3913-63-1) → (±)-methyl cis-9,10-methylenehexadecanoate (10152-61-1,36254-90-7)

Guidance literature:

diiodomethane; With diethylzinc; trifluoroacetic acid; In hexane; dichloromethane; at 0 ℃; for 0.333333h; Inert atmosphere;

(Z)-9-hexadecenoic acid methyl ester; In hexane; dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01914

Reference yield:

cis-9-hexadecenoic acid (373-49-9,2091-29-4) → (±)-methyl cis-9,10-methylenehexadecanoate (10152-61-1,36254-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol; toluene; diethyl ether / 0.5 h / 0 - 20 °C

2.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 0.33 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 - 20 °C / Inert atmosphere

With diethylzinc; trifluoroacetic acid; In methanol; diethyl ether; hexane; dichloromethane; toluene;

DOI:10.1021/acs.orglett.9b01914

Reference yield:

→ (±)-methyl cis-9,10-methylenehexadecanoate (10152-61-1,36254-90-7)

Guidance literature:

/BRN= 726110/, CH2I2, Zn-Cu-Paar;

upstream raw materials:

diiodomethane

(Z)-9-hexadecenoic acid methyl ester

cis-9-hexadecenoic acid

Downstream raw materials:

(±)-cis-9,10-methylenehexadecanoic acid

Refernces

• 1、 Dolke, Franziska,Dong, Chuanfu,Bandi, Siva,Paetz, Christian,Glauser, Gaétan,Von Reu?, Stephan H.. "Ascaroside Signaling in the Bacterivorous Nematode Caenorhabditis remanei Encodes the Growth Phase of Its Bacterial Food Source". . p. 5832 - 5837. Retrieved 2019.