P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide

Base Information

• Chemical Name: P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide
• CAS No.: 82572-06-3
• Molecular Formula: C₂₀H₁₈NOP
• Molecular Weight: 319.343
• Mol file: 82572-06-3.mol

Synonyms:P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide

Chemical Property of P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide

There total 4 articles about P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

acetophenone oxime (613-91-2) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide (82572-06-3)

Guidance literature:

With triethylamine; In Dimethyl ether; dichloromethane; at -45 - 20 ℃;

Reference yield: 20.0%

C29H27N2O3PS → [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) + P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide (82572-06-3)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201804099

Reference yield:

acetophenone (98-86-2) → P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide (82572-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂OH*HCl; NaOAc / ethanol; H₂O / Heating

2: triethylamine / petroleum ether; CH₂Cl₂ / -45 - -40 °C

With hydroxylamine hydrochloride; sodium acetate; triethylamine; In ethanol; dichloromethane; water; Petroleum ether;

DOI:10.1021/jo062006y

upstream raw materials:

acetophenone oxime

chloro-diphenylphosphine

acetophenone

diphenylphosphinamide

Downstream raw materials:

1,5-diphenyl-3-(p-methylphenyl)-1,5-pentanedione

1-phenyl-3-(4-tolyl)propan-1-one

4-(4-methylphenyl)-2,6-diphenylpyridine

3-(4-chlorophenyl)-1-phenylpropan-1-one

Refernces

• 1、 Shao, Xinxin,Li, Kangnan,Malcolmson, Steven J.. "Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines". supporting information. p. 7083 - 7087. Retrieved 2018/05/29.
• 2、 Yang, Fan,Chen, Jingchao,Shen, Guoli,Zhang, Xuexin,Fan, Baomin. "Asymmetric transfer hydrogenation reactions of: N -sulfonylimines by using alcohols as hydrogen sources". supporting information. p. 4963 - 4966. Retrieved 2018/05/23.