2-(2,5-dimethoxyphenyl)-2-trimethylsilyloxyacetonitrile

Base Information

• Chemical Name: 2-(2,5-dimethoxyphenyl)-2-trimethylsilyloxyacetonitrile
• CAS No.: 141367-35-3
• Molecular Formula: C₁₃H₁₉NO₃Si
• Molecular Weight: 265.384
• Mol file: 141367-35-3.mol

Synonyms:2-(2,5-dimethoxyphenyl)-2-trimethylsilyloxyacetonitrile

Chemical Property of 2-(2,5-dimethoxyphenyl)-2-trimethylsilyloxyacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,5-dimethoxyphenyl)-2-trimethylsilyloxyacetonitrile

There total 1 articles about 2-(2,5-dimethoxyphenyl)-2-trimethylsilyloxyacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trimethylsilyl cyanide (7677-24-9) + 2,5-dimethoxybenzaldehyde (93-02-7) → 2-(2,5-dimethoxyphenyl)-2-trimethylsilyloxyacetonitrile (141367-35-3)

Guidance literature:

With C₂₉H₃₈AlN₄O₂⁽¹⁺⁾*CF₃O₃S^(1-); at 20 ℃; for 0.333333h; Catalytic behavior; Inert atmosphere; Schlenk technique;

DOI:10.1039/c7dt01760j

Reference yield: 54.0%

2-(2,5-dimethoxyphenyl)-2-trimethylsilyloxyacetonitrile (141367-35-3) → desglymidodrine (3600-87-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 1h; Heating;

Reference yield:

2-(2,5-dimethoxyphenyl)-2-trimethylsilyloxyacetonitrile (141367-35-3) → 1-(2',5'-dimethoxyphenyl)-2-aminoethanol hydrochloride (60407-53-6)

Guidance literature:

With hydrogenchloride; lithium aluminium tetrahydride; Yield given. Multistep reaction; 1.) THF, reflux, 2 h, 2.) methanol, ether;

DOI:10.1016/S0223-5234(97)82773-0

upstream raw materials:

trimethylsilyl cyanide

2,5-dimethoxybenzaldehyde

Downstream raw materials:

desglymidodrine

2-(2,5-dimethoxyphenyl)-2-hydroxyacetonitrile

1-(2',5'-dimethoxyphenyl)-2-aminoethanol hydrochloride

5-(2,5-Dimethoxy-phenyl)-oxazolidine-2,4-dione

Refernces

• 1、 Sharma, Mahendra Kumar,Sinhababu, Soumen,Mukherjee, Goutam,Rajaraman, Gopalan,Nagendran, Selvarajan. "A cationic aluminium complex: An efficient mononuclear main-group catalyst for the cyanosilylation of carbonyl compounds". supporting information. p. 7672 - 7676. Retrieved 2017/07/11.
• 2、 Pirrung, Michael C.,Shuey, Steven W.. "Photoremovable Protecting Groups for Phosphorylation of Chiral Alcohols. Asymmetric Synthesis of Phosphotriesters of (-)-3',5'-Dimethoxybenzoin". . p. 3890 - 3897. Retrieved 2007/10/02.