3600-87-1 Usage
Description
2-Amino-1-(2,5-dimethoxyphenyl)ethanol, also known as Midrodine Related Compound A, is an aromatic ether that features a 1,4-dimethoxybenzene molecule substituted at position 2 by a 2-amino-1-hydroxyethyl group. It is the immediate and active metabolite of midrodine, functioning as a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. 2-Amino-1-(2,5-dimethoxyphenyl)ethanol is presented as a white powder.
Uses
Used in Pharmaceutical Industry:
2-Amino-1-(2,5-dimethoxyphenyl)ethanol is used as an active metabolite for the treatment of hypotensive states. As a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it induces alpha-adrenergic receptor stimulation of both arterial and venous systems without direct central nervous system or cardiac effects. This makes it a valuable compound in the development of medications for specific hypotensive conditions.
Used in Metabolite Research:
In the field of metabolite research, 2-Amino-1-(2,5-dimethoxyphenyl)ethanol serves as a key compound for understanding the metabolic pathways and effects of midrodine. This knowledge can be applied to optimize drug formulations, improve pharmacokinetics, and develop new therapeutic strategies for various medical conditions.
Used in Drug Development:
2-Amino-1-(2,5-dimethoxyphenyl)ethanol is used as a starting point for the development of new drugs with improved pharmacological properties. Its unique structure and activity can be leveraged to design novel compounds with enhanced efficacy, selectivity, and safety profiles for the treatment of various diseases and disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 3600-87-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,0 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3600-87:
(6*3)+(5*6)+(4*0)+(3*0)+(2*8)+(1*7)=71
71 % 10 = 1
So 3600-87-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3
3600-87-1Relevant articles and documents
Preparation method of 1-(2,5-dimethoxy phenyl)-2-aminoethanol
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Paragraph 0032; 0035; 0036, (2017/03/08)
The invention provides a preparation method of hydrochloric acid midodrine intermediate 1-(2,5-dimethoxy phenyl)-2-aminoethanol, comprising the steps of adopting 2,5-dimethoxy benzaldehyde as the raw material to condense with nitromethane under the effect of alkali to obtain 1-(2,5-dimethoxy phenyl)-2-nitroethanol, reducing 1-(2,5-dimethoxy phenyl)-2-nitroethanol with a boron reductant to obtain 1-(2,5-dimethoxy phenyl)-2-aminoethanol. The preparation method of 1-(2,5-dimethoxy phenyl)-2-aminoethanol has the advantages of being mild in reaction conditions, simple in the operation process, high in yield, environment-friendly and low in production cost, and is applicable to industrial production.
Synthesis of midodrine HCI from a novel intermediate 1-(2′,5′-dimethoxyphenyl)-2-azidoethanone
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, (2008/06/13)
Midodrine hydrochloride, ±1-(2′,5′-dimethoxyphenyl)-2-glycineamido-ethanol-(1)-HCl, is prepared from a novel intermediate, 1-(2′,5′-dimethoxyphenyl)-2-azidoethanone.
Synthesis and adrenergic properties of new duplicated analogs of methoxamine
Perez,Rosell,Mauleon,Carganico
, p. 1155 - 1166 (2007/10/02)
New duplicated analogs of the α1-selective agonist methoxamine and of its cyclic derivative 5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthylamine have been synthesized and tested for their adrenergic properties. All the compounds prepared, presenting a polymethylene spacer of varying length between two units of the active structure, turned out to be completely devoid of any α-stimulating activity. Surprisingly, some of them showed a marked β-adrenergic agonistic effect, being the most interesting compound active at nanomolar concentration.
