4-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-3,5-dimethoxybenzoic acid ethyl ester

Base Information

• Chemical Name: 4-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-3,5-dimethoxybenzoic acid ethyl ester
• CAS No.: 1437306-81-4
• Molecular Formula: C₁₉H₃₁NO₈
• Molecular Weight: 401.457
• Mol file: 1437306-81-4.mol

Synonyms:4-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-3,5-dimethoxybenzoic acid ethyl ester

Chemical Property of 4-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-3,5-dimethoxybenzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-3,5-dimethoxybenzoic acid ethyl ester

There total 3 articles about 4-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-3,5-dimethoxybenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)-3,5-dimethoxybenzoic acid ethyl ester (1437306-59-6) → 4-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-3,5-dimethoxybenzoic acid ethyl ester (1437306-81-4)

Guidance literature:

With hydrogen; palladium diacetate; In ethanol;

DOI:10.1021/bc400074w

Reference yield:

4-hydroxy-3,5-dimethoxybenzoic acid ethyl ester (3943-80-4) → 4-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-3,5-dimethoxybenzoic acid ethyl ester (1437306-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C

2: palladium diacetate; hydrogen / ethanol

With hydrogen; palladium diacetate; caesium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/bc400074w

Reference yield:

3,5-dimethoxy-4-hydroxybenzoic acid (530-57-4) → 4-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)-3,5-dimethoxybenzoic acid ethyl ester (1437306-81-4)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 0 - 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C

3: palladium diacetate; hydrogen / ethanol

With thionyl chloride; hydrogen; palladium diacetate; caesium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/bc400074w

upstream raw materials:

3,5-dimethoxy-4-hydroxybenzoic acid

4-hydroxy-3,5-dimethoxybenzoic acid ethyl ester

4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)-3,5-dimethoxybenzoic acid ethyl ester

Downstream raw materials:

4-(2-(2-(2-(2-N-Boc-aminoethoxy)ethoxy)ethoxy)ethoxy)-3,5-dimethoxybenzoic acid ethyl ester

C₃₉H₅₅N₃O₁₄

C₃₈H₅₁N₃O₁₄

C₃₃H₄₆N₄O₁₂*C₂HF₃O₂

Refernces