4-(2-Chloroethyl)pyridine

Base Information

• Chemical Name: 4-(2-Chloroethyl)pyridine
• CAS No.: 28148-48-3
• Molecular Formula: C7H8 Cl N
• Molecular Weight: 141.6
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50499889
• Nikkaji Number: J2.093.542A
• Wikidata: Q82351103
• Mol file: 28148-48-3.mol

Synonyms:4-(2-Chloroethyl)pyridine;28148-48-3;4-(2-CHLORO-ETHYL)-PYRIDINE;Pyridine, 4-(2-chloroethyl)-;2-(4-pyridyl)ethyl chloride;SCHEMBL2551287;DTXSID50499889;DPXZCTJBRDTGFZ-UHFFFAOYSA-N;AKOS005216054;SB53328;EN300-1692581

Chemical Property of 4-(2-Chloroethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.094mmHg at 25°C
• Refractive Index: 1.523
• Boiling Point: 231.646°C at 760 mmHg
• Flash Point: 116.156°C
• PSA: 12.89000
• Density: 1.116g/cm³
• LogP: 1.86290
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 141.0345270
• Heavy Atom Count: 9
• Complexity: 69.3

Purity/Quality:

99%, ^*data from raw suppliers

4-(2-CHLOROETHYL)PYRIDINE 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC=C1CCCl
• Use Description: 4-(2-Chloro-ethyl)-pyridine, a specific chemical compound, serves diverse roles in various fields. In the pharmaceutical sector, it acts as a crucial intermediate in the synthesis of pharmaceutical compounds, contributing to the creation of molecules with potential therapeutic applications. In organic chemistry, this compound functions as a versatile building block, enabling the construction of complex molecular structures and supporting advancements in chemical research. Additionally, in agrochemicals, it may contribute to the formulation of pesticides, aiding in pest management and crop protection. Its multifaceted applications in pharmaceuticals, chemistry, and agriculture highlight its significance in driving innovation, scientific discovery, and practical solutions across these essential domains.

Technology Process of 4-(2-Chloroethyl)pyridine

There total 3 articles about 4-(2-Chloroethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

4-(2-hydroxyethyl)pyridine (5344-27-4) → 2-(pyridin-4-yl)ethyl chloride (28148-48-3)

Guidance literature:

With tetrachloromethane; triphenylphosphine; at 20 ℃; for 72h;

DOI:10.1021/jo040117w

Reference yield:

→ 2-(pyridin-4-yl)ethyl chloride (28148-48-3)

Guidance literature:

With hydrogenchloride; at 100 ℃; im Rohr;

Reference yield:

→ 2-(pyridin-4-yl)ethyl chloride (28148-48-3)

Guidance literature:

entspr. Alkohol, Thionylchlorid;

upstream raw materials:

4-(2-hydroxyethyl)pyridine

Downstream raw materials:

3-(pyridin-4-yl)propanenitrile

1,1,1-trichloro-4-methoxy-3-[4]pyridyl-butan-2-ol

C₁₂H₁₉N₃

3-pyridin-4-yl-propionic acid

Refernces

• 1、 Menghin, Sonja,Pertz, Heinz H.,Kramer, Kai,Seifert, Roland,Schunack, Walter,Elz, Sigurd. "Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen: Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists". . p. 5458 - 5470. Retrieved 2007/10/03.