2,3,5-Trimethoxyphenol

Base Information

• Chemical Name: 2,3,5-Trimethoxyphenol
• CAS No.: 20660-35-9
• Molecular Formula: C₉H₁₂O₄
• Molecular Weight: 184.192
• DSSTox Substance ID: DTXSID001314333
• Nikkaji Number: J141.505K
• Mol file: 20660-35-9.mol

Synonyms:2,3,5-trimethoxyphenol;20660-35-9;SCHEMBL1402215;DTXSID001314333

Chemical Property of 2,3,5-Trimethoxyphenol

Chemical Property:

• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 184.07355886
• Heavy Atom Count: 13
• Complexity: 151

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=C(C(=C1)OC)OC)O

Technology Process of 2,3,5-Trimethoxyphenol

There total 18 articles about 2,3,5-Trimethoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,5-Trimethoxy-3-p-tosyloxy-benzol (20032-41-1) → 2,3,5-Trimethoxy-phenol (20660-35-9)

Guidance literature:

With potassium hydroxide; In methanol;

DOI:10.1039/j39680002125

Reference yield:

2,5-Dimethoxy-3-benzolsulfonyloxy-phenol (20032-37-5) → 2,3,5-Trimethoxy-phenol (20660-35-9)

Guidance literature:

Multi-step reaction with 2 steps

2: aq. KOH / methanol

With potassium hydroxide; In methanol;

DOI:10.1039/j39680002125

Reference yield:

4-Amino-3,5-bis-benzolsulfonyloxy-phenol (20032-70-6) → 2,3,5-Trimethoxy-phenol (20660-35-9)

Guidance literature:

Multi-step reaction with 6 steps

1: HNO₃ / ethanol

2: Na₂S₂O₄ / aq. acetic acid

3: aq. NaOH

4: aq. KOH / methanol

6: aq. KOH / methanol

With potassium hydroxide; sodium hydroxide; sodium dithionite; nitric acid; In methanol; ethanol; acetic acid;

DOI:10.1039/j39680002125

upstream raw materials:

1-(benzyloxy)-2,3,5-trimethoxybenzene

1,2,5-Trimethoxy-3-p-tosyloxy-benzol

3-acetyl-6-(1-carboxy-1-methyl-ethoxy)-2,4,5-trimethoxy-benzoic acid

2,5-Dimethoxy-3-benzolsulfonyloxy-phenol

Downstream raw materials:

1,2,3,5-tetramethoxybenzene