4-Hydrazinylpyrimidine

Base Information

• Chemical Name: 4-Hydrazinylpyrimidine
• CAS No.: 22930-71-8
• Molecular Formula: C4H6 N4
• Molecular Weight: 110.11724
• European Community (EC) Number: 818-578-5
• Mol file: 22930-71-8.mol

Synonyms:4-Hydrazinylpyrimidine;4-hydrazinopyrimidine;22930-71-8;pyrimidin-4-ylhydrazine;4(1H)-Pyrimidinone, hydrazone (9CI);MFCD09863254;4(1H)-Pyrimidinone, hydrazone;SCHEMBL2086404;QIEQDFYXVYQLLU-UHFFFAOYSA-N;AKOS010502648;SB55547;(Z)-4-hydrazono-1,4-dihydropyrimidine;AS-75589;SY185630;BB 0262488;CS-0106397;EN300-80992;N12626

Chemical Property of 4-Hydrazinylpyrimidine

Chemical Property:

• Melting Point: 132-134 °C (decomp)
• Boiling Point: 246.3±23.0 °C(Predicted)
• PKA: 8.00±0.70(Predicted)
• PSA: 63.83000
• Density: 1.39±0.1 g/cm3(Predicted)
• LogP: 0.53550
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 110.059246208
• Heavy Atom Count: 8
• Complexity: 65.1

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-Hydrazinopyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CN=C1NN

Technology Process of 4-Hydrazinylpyrimidine

There total 4 articles about 4-Hydrazinylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.37%

→ pyrimidin-4-ylhydrazine (22930-71-8)

Guidance literature:

With hydrazine hydrate; In ethanol; at 70 ℃; for 2h; Inert atmosphere;

Reference yield: 25.0%

(2-chloropyrimidin-4-yl)hydrazine (52476-87-6) → pyrimidin-4-ylhydrazine (22930-71-8)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; In methanol; at 55 ℃; for 15h;

Reference yield:

6-chloro-4-hydrazinopyrimidine (5767-35-1) → pyrimidin-4-ylhydrazine (22930-71-8)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; at 50 - 60 ℃; for 15h;

DOI:10.1021/jm970255w

upstream raw materials:

4-methoxypyrimidine

6-chloro-4-hydrazinopyrimidine

(2-chloropyrimidin-4-yl)hydrazine

Refernces

• 1、 -. "HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF". Page/Page column 76. . Retrieved 2013/03/26.
• 2、 Easmon,Heinisch,Purstinger,Langer,Osterreicher,Grunicke,Hofmann. "Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: Synthesis and antiproliferative activity". . p. 4420 - 4425. Retrieved 2007/10/03.