2-Chloro-4-hydrazinopyrimidine

Base Information

• Chemical Name: 2-Chloro-4-hydrazinopyrimidine
• CAS No.: 52476-87-6
• Molecular Formula: C4H5ClN4
• Molecular Weight: 144.564
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00582179
• Nikkaji Number: J2.385.939D
• Wikidata: Q72451710
• Mol file: 52476-87-6.mol

Synonyms:2-Chloro-4-hydrazinopyrimidine;52476-87-6;2-chloro-4-hydrazinylpyrimidine;(2-chloropyrimidin-4-yl)hydrazine;MFCD06658201;(2-Chloro-pyrimidin-4-yl)-hydrazine;2-chloro-6-hydrazinopyrimidine;SCHEMBL1782191;2-chloro-4-hydrazinyl-pyrimidine;DTXSID00582179;NOTCVZXATRYXPI-UHFFFAOYSA-N;AKOS005256085;AC-6197;DS-0260;SB55763;SY066099;AM20100290;CS-0113126;EN300-75759;A829105;J-508745

Chemical Property of 2-Chloro-4-hydrazinopyrimidine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.684
• Boiling Point: 406.266 °C at 760 mmHg
• PKA: 3.50±0.70(Predicted)
• Flash Point: 199.503 °C
• PSA: 63.83000
• Density: 1.53 g/cm³
• LogP: 1.18890
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 144.0202739
• Heavy Atom Count: 9
• Complexity: 88.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-4-hydrazinopyrimidine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

Useful:

• Canonical SMILES: C1=CN=C(N=C1NN)Cl

Technology Process of 2-Chloro-4-hydrazinopyrimidine

There total 4 articles about 2-Chloro-4-hydrazinopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

2,6-Dichloropyrimidine (3934-20-1) → (2-chloropyrimidin-4-yl)hydrazine (52476-87-6)

Guidance literature:

With hydrazine hydrate; In isopropyl alcohol; at 20 ℃; for 1h;

Reference yield: 23.0%

2,6-Dichloropyrimidine (3934-20-1) + hydrazine (302-01-2,78206-91-4,119775-10-9,75013-58-0) → (2-chloropyrimidin-4-yl)hydrazine (52476-87-6)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 2h;

Reference yield:

2,6-Dichloropyrimidine (3934-20-1) → 4-chloro-2-hydrazinopyrimidine (1158984-54-3) + (2-chloropyrimidin-4-yl)hydrazine (52476-87-6)

Guidance literature:

With triethylamine; hydrazine; In ethanol; water; at 20 ℃; for 24h;

upstream raw materials:

2,6-Dichloropyrimidine

hydrazine

Downstream raw materials:

7-chloro-[1,2,4]triazolo[4,3-c]pyrimidine

pyrimidin-4-ylhydrazine

1-(azepan-2-ylidene)-2-(2-chloropyrimidin-4-yl)hydrazine

C₁₁H₉ClN₄

Refernces

• 1、 -. "NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND USE". Paragraph 0167. . Retrieved 2019/01/17.
• 2、 -. "Compound and organic electroluminescent device". Paragraph 0126; 0127; 0128; 0129. . Retrieved 2019/01/08.