(S)-1-Pyridin-2-yl-ethylamine

Base Information

• Chemical Name: (S)-1-Pyridin-2-yl-ethylamine
• CAS No.: 27854-90-6
• Molecular Formula: C7H10 N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• European Community (EC) Number: 822-578-0
• Nikkaji Number: J64.088C
• Mol file: 27854-90-6.mol

Synonyms:27854-90-6;(S)-1-Pyridin-2-yl-ethylamine;(S)-1-(Pyridin-2-yl)ethanamine;(1S)-1-pyridin-2-ylethanamine;(S)-1-(2-Pyridyl)ethylamine;(1S)-1-(pyridin-2-yl)ethan-1-amine;(-)-(S)-1-(2-Pyridyl)ethanamine;MFCD08752493;2-Pyridinemethanamine, alpha-methyl-, (alphaS)-;SCHEMBL751028;(S)-1-Pyridin-2-ylethylamine;PDNHLCRMUIGNBV-LURJTMIESA-N;CS-M3539;(s)-1-amino-1-(2-pyridyl)-ethane;AKOS016842300;PS-9214;AC-31020;AC-31022;AS-80792;EN300-58773

Chemical Property of (S)-1-Pyridin-2-yl-ethylamine

Chemical Property:

• Boiling Point: 195℃
• PKA: 9.05±0.39(Predicted)
• Flash Point: 92℃
• PSA: 38.91000
• Density: 1.018
• LogP: 1.80160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

98% or more ^*data from raw suppliers

(S)-1-(Pyridin-2-yl)ethanamine 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=N1)N
• Isomeric SMILES: C[C@@H](C1=CC=CC=N1)N

Technology Process of (S)-1-Pyridin-2-yl-ethylamine

There total 5 articles about (S)-1-Pyridin-2-yl-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetylpyridine (1122-62-9) + 1,5-diaminopentane (462-94-2) → 2,3,4,5-tetrahydropyridine (505-18-0) + (S)-1-(2-pyridyl)ethylamine (27854-90-6)

Guidance literature:

With spuC gene from Pseudomonas putida; In dimethyl sulfoxide; at 40 ℃; for 24h; pH=9; Reagent/catalyst; enantioselective reaction; Enzymatic reaction;

DOI:10.1039/c6gc02102f

Reference yield:

2-acetylpyridine (1122-62-9) + 1,4-diaminobutane (110-60-1) → 1-pyrroline (5724-81-2) + (S)-1-(2-pyridyl)ethylamine (27854-90-6) + (R)-1-(pyridin-2-yl)ethanamine (27854-90-6,42088-91-5,42732-17-2,45695-03-2)

Guidance literature:

With spuC gene from Pseudomonas chlororaphis subsp. aureofaciens; In dimethyl sulfoxide; at 40 ℃; for 24h; pH=9; enantioselective reaction; Enzymatic reaction;

DOI:10.1039/c6gc02102f

Reference yield:

2-acetylpyridine (1122-62-9) + 1,4-diaminobutane (110-60-1) → 1-pyrroline (5724-81-2) + (S)-1-(2-pyridyl)ethylamine (27854-90-6) + (R)-1-(pyridin-2-yl)ethanamine (27854-90-6,42088-91-5,42732-17-2,45695-03-2)

Guidance literature:

With spuC gene from Pseudomonas chlororaphis subsp. aureofaciens; In dimethyl sulfoxide; at 40 ℃; for 24h; pH=9; enantioselective reaction; Enzymatic reaction;

DOI:10.1039/c6gc02102f

upstream raw materials:

2-acetylpyridine

1,4-diaminobutane

1,5-diaminopentane

N-butylamine

Downstream raw materials:

[R]-7-[2-(5-trifluoromethyl-pyridin-2-yl)-benzoylamino]-quinoline-3-carboxylic acid (1-pyridin-2-yl-ethyl)-amide

[R]-7-{[2-(4-trifluoromethyl-phenyl)-pyridine-3-carbonyl]-amino}-quinoline-3-carboxylic acid (1-pyridin-2-yl-ethyl)-amide

C₂₃H₂₄N₂O₃S

Refernces

• 1、 Galman, James L.,Slabu, Iustina,Weise, Nicholas J.,Iglesias, Cesar,Parmeggiani, Fabio,Lloyd, Richard C.,Turner, Nicholas J.. "Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases". supporting information. p. 361 - 366. Retrieved 2017/08/14.