6-Methoxy-2-methyl-1-tetralone

Base Information

• Chemical Name: 6-Methoxy-2-methyl-1-tetralone
• CAS No.: 27752-24-5
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.242
• European Community (EC) Number: 608-138-9
• DSSTox Substance ID: DTXSID60455779
• Nikkaji Number: J956.513B
• Mol file: 27752-24-5.mol

Synonyms:6-METHOXY-2-METHYL-1-TETRALONE;27752-24-5;6-methoxy-2-methyl-3,4-dihydro-2H-naphthalen-1-one;1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy-2-methyl-;MFCD00156697;SCHEMBL630841;2-Methyl-6-Methoxy-1-Tetralone;DTXSID60455779;ZTZCDPZRYPANDJ-UHFFFAOYSA-N;2-Methyl-6-methoxytetralin-1-one;AKOS006273327;BS-16839;SY268173;CS-0160567;N14244;6-methoxy-2-methyl-1,2,3,4-tetrahydronaphthalen-1-one

Chemical Property of 6-Methoxy-2-methyl-1-tetralone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.529
• Boiling Point: 326.614°C at 760 mmHg
• Flash Point: 149.731°C
• PSA: 26.30000
• Density: 1.076g/cm³
• LogP: 2.46020
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 190.099379685
• Heavy Atom Count: 14
• Complexity: 224

Purity/Quality:

97% ^*data from raw suppliers

6-Methoxy-2-methyl-1-tetralone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCC2=C(C1=O)C=CC(=C2)OC

Technology Process of 6-Methoxy-2-methyl-1-tetralone

There total 25 articles about 6-Methoxy-2-methyl-1-tetralone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-[1-Benzyloxy-meth-(E)-ylidene]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one → 6-methoxy-2-methyl-3,4-dihydronaphthalen-1(2H)-one (27752-24-5,888007-82-7,1129429-21-5,745033-23-2)

Guidance literature:

With TEA; hydrogen; platinum(II) oxide; In isopropyl alcohol; under 760 Torr; Ambient temperature;

DOI:10.1071/CH9842279

Reference yield: 99.0%

C12H14O2 (1443497-75-3) → 6-methoxy-2-methyl-3,4-dihydronaphthalen-1(2H)-one (27752-24-5,888007-82-7,1129429-21-5,745033-23-2)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 1,3-di-tert-butylimidazol-2-ylidene; In 1,3,5-trimethyl-benzene; at 130 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201206186

Reference yield: 85.0%

2-(Bis-methylsulfanyl-methylene)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one (51507-10-9) → 6-methoxy-2-methyl-3,4-dihydronaphthalen-1(2H)-one (27752-24-5,888007-82-7,1129429-21-5,745033-23-2)

Guidance literature:

With dichloro(N,N,N’,N‘-tetramethylethylenediamine)zinc; zinc; In ethanol; for 16h; Heating;

DOI:10.1016/0040-4020(96)00139-1

upstream raw materials:

4-(3-methoxy-phenyl)-2-methyl-butyric acid

2-benzoyloxymethylene-6-methoxy-1-Tetralone

17β-hydroxy-5-methoxy-de-A-oestra-5,7,9,14-tetraene

formaldehyd

Downstream raw materials:

(R)-6-methoxy-2-methyl-1-tetralone

(S)-6-methoxy-2-methyl-1-tetralone

3,3a,4,5-Tetrahydro-7-methoxy-3a-methyl-2H-benzinden-2-on

1ζ-acetoxy-6-methoxy-2-(p-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydronaphthalene

Refernces

• 1、 Mamidala, Ramesh,Biswal, Priyabrata,Subramani, M. Siva,Samser, Shaikh,Venkatasubbaiah, Krishnan. "Palladacycle-Phosphine Catalyzed Methylation of Amines and Ketones Using Methanol". . p. 10472 - 10480. Retrieved 2019/08/20.
• 2、 Borah, Ashwini,Goswami, Limi,Neog, Kashmiri,Gogoi, Pranjal. "DMF Dimethyl Acetal as Carbon Source for α-Methylation of Ketones: A Hydrogenation-Hydrogenolysis Strategy of Enaminones". . p. 4722 - 4728. Retrieved 2015/05/13.