7-methoxy-1H-benzo[d]imidazole

Base Information

• Chemical Name: 7-methoxy-1H-benzo[d]imidazole
• CAS No.: 27080-53-1
• Molecular Formula: C8H8 N2 O
• Molecular Weight: 148.16192
• Hs Code.: 2933990090
• European Community (EC) Number: 844-373-5
• DSSTox Substance ID: DTXSID10566263
• Wikidata: Q82451802
• Mol file: 27080-53-1.mol

Synonyms:7-methoxy-1H-benzo[d]imidazole;27080-53-1;4-METHOXY-1H-BENZIMIDAZOLE;1H-Benzimidazole, 4-methoxy-;7-methoxy-1H-Benzimidazole;4-methoxy-1H-1,3-benzodiazole;SCHEMBL10140;DTXSID10566263;WLZ3348;CBA08053;MFCD11973699;AKOS006347217;DS-9179;CS-0043995;C74404;EN300-365082;A925040;Z1198182091

Chemical Property of 7-methoxy-1H-benzo[d]imidazole

Chemical Property:

• Vapor Pressure: 6.07E-06mmHg at 25°C
• Melting Point: 168 °C
• Refractive Index: 1.647
• Boiling Point: 390.2°Cat760mmHg
• PKA: 12.94±0.30(Predicted)
• Flash Point: 141.7°C
• PSA: 37.91000
• Density: 1.244g/cm³
• LogP: 1.57150
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.063662883
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxy-1H-benzimidazole 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1N=CN2

Technology Process of 7-methoxy-1H-benzo[d]imidazole

There total 8 articles about 7-methoxy-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N1-benzyl-4-methoxybenzimidazole → 4-methoxy-1H-benzo[d]imidazole (27080-53-1)

Guidance literature:

With triethylsilane; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.03.127

Reference yield: 96.0%

N3-benzyl-4-methoxybenzimidazole (33235-48-2) → 4-methoxy-1H-benzo[d]imidazole (27080-53-1)

Guidance literature:

With triethylsilane; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.03.127

Reference yield: 83.9%

formic acid (64-18-6) + 3-methoxybenzene-1,2-diamine (37466-89-0) → 4-methoxy-1H-benzo[d]imidazole (27080-53-1)

Guidance literature:

Reflux;

DOI:10.1080/10286020.2011.556091

upstream raw materials:

formic acid

3-methoxybenzene-1,2-diamine

sodium formate

2-Amino-3-nitrophenol

Downstream raw materials:

N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-3,4-dimethylbenzenesulfonamide

N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-3,4-dimethoxybenzenesulfonamide

N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-3-chloro-4-methylbenzenesulfonamide

N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-3-nitro-4-methylbenzenesulfonamide

Refernces

• 1、 -. "SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS". Paragraph 00297; 00309-00310; 00371. . Retrieved 2021/04/01.
• 2、 Zhou, Jie,Jin, Jing,Zhang, Yi,Yin, Yuwen,Chen, Xiaoguang,Xu, Bailing. "Synthesis and antiproliferative evaluation of novel benzoimidazole- contained oxazole-bridged analogs of combretastatin A-4". . p. 222 - 232. Retrieved 2013/10/01.