(S)-Enflurane

Base Information

• Chemical Name: (S)-Enflurane
• CAS No.: 22194-21-4
• Molecular Formula: C₃H₂ClF₅O
• Molecular Weight: 184.493
• Mol file: 22194-21-4.mol

Synonyms:Ethane,2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-, (S)-; Ether,2-chloro-1,1,2-trifluoroethyl difluoromethyl, (+)- (8CI);(+)-1,1,2-Trifluoro-2-chloroethyl difluoromethyl ether; (+)-Enflurane;(S)-(+)-Enflurane; (S)-Enflurane

Chemical Property of (S)-Enflurane

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(2S)-2-CHLORO-1-(DIFLUOROMETHOXY)-1,1,2-TRIFLUOROETHANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Enflurane

There total 5 articles about (S)-Enflurane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ enflurane (13838-16-9,22194-21-4,22194-22-5)

Guidance literature:

Reference yield:

(2-chloro-1,1,2-trifluoroethyl)dichloromethylether (428-96-6) → enflurane (13838-16-9,22194-21-4,22194-22-5)

Guidance literature:

With hydrogen fluoride; antimonypentachloride; at 0 ℃;

DOI:10.1021/jm00276a008

Reference yield:

2-chloroethyl methyl ether (627-42-9) → 2-Chloro-1,1,2-trifluoroethyl fluoromethyl ether (5073-63-2) + enflurane (13838-16-9,22194-21-4,22194-22-5) + 2-Chloro-1,2-difluoroethyl fluoromethyl ether + 2-Chloro-1,2-difluoroethyl difluoromethyl ether

Guidance literature:

With potassium tetrafluorocobaltate; at 250 ℃; Yield given. Further byproducts given. Yields of byproduct given;

DOI:10.1016/S0022-1139(96)03549-X

upstream raw materials:

(2-chloro-1,1,2-trifluoroethyl)dichloromethylether

2-chloroethyl methyl ether

enflurane

Downstream raw materials:

(R)-(-)-Enfluran

(+)-(S)-enflurane

Refernces

• 1、 Coe, Paul L.,Rowbotham, Roger A.,Tatlow, John Colin. "Chloropolyfluoro-derivatives of ethyl methyl ether". . p. 9 - 12. Retrieved 2007/10/03.
• 2、 -. "Process for adjusting the halogen content of halogenated aliphatic ethers". . . Retrieved 2008/06/13.