C₂₇H₂₆N₃OP

Base Information

• Chemical Name: C₂₇H₂₆N₃OP
• CAS No.: 215734-34-2
• Molecular Formula: C₂₇H₂₆N₃OP
• Molecular Weight: 439.497
• Mol file: 215734-34-2.mol

Synonyms:C₂₇H₂₆N₃OP

Chemical Property of C₂₇H₂₆N₃OP

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₇H₂₆N₃OP

There total 2 articles about C₂₇H₂₆N₃OP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-amino-N-isopropyl-nicotinamide (34757-95-4) + triphenylphosphine (603-35-0) → C27H26N3OP (215734-34-2)

Guidance literature:

With triethylamine; In benzene; at 2 ℃; Heating;

DOI:10.1055/s-1998-2170

Reference yield:

2-aminopyridin-3-carboxylic acid (5345-47-1) → C27H26N3OP (215734-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / diethylphosphoryl cyanide, Et₃N / 1,2-dimethoxy-ethane / 1.) 0 deg C, 1 h, 2.) 40 deg C, 1 h

2: 91 percent / Et₃N / benzene; various solvent(s) / 2 °C / Heating

With diethylphosphoryl cyanide; triethylamine; In 1,2-dimethoxyethane; benzene;

DOI:10.1055/s-1998-2170

Reference yield: 79.0%

4-nitro-benzoyl chloride (122-04-3) + C27H26N3OP (215734-34-2) → 3-Isopropyl-2-(4-nitro-phenyl)-3H-pyrido[2,3-d]pyrimidin-4-one

Guidance literature:

With triethylamine; In toluene; for 2h; Heating;

DOI:10.1055/s-1998-2170

upstream raw materials:

2-amino-N-isopropyl-nicotinamide

triphenylphosphine

2-aminopyridin-3-carboxylic acid

Refernces