1-trifluoromethyl-4-trimethylsilyloxybenzene

Base Information

• Chemical Name: 1-trifluoromethyl-4-trimethylsilyloxybenzene
• CAS No.: 41571-86-2
• Molecular Formula: C₁₀H₁₃F₃OSi
• Molecular Weight: 234.293
• Mol file: 41571-86-2.mol

Synonyms:1-trifluoromethyl-4-trimethylsilyloxybenzene

Chemical Property of 1-trifluoromethyl-4-trimethylsilyloxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-trifluoromethyl-4-trimethylsilyloxybenzene

There total 2 articles about 1-trifluoromethyl-4-trimethylsilyloxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-hydroxybenzotrifluoride (402-45-9) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 1-trifluoromethyl-4-trimethylsilyloxybenzene (41571-86-2)

Guidance literature:

at 100 ℃;

DOI:10.1039/b808374f

Reference yield:

chloro-trimethyl-silane (75-77-4) + 4-hydroxybenzotrifluoride (402-45-9) → 1-trifluoromethyl-4-trimethylsilyloxybenzene (41571-86-2)

Guidance literature:

4-hydroxybenzotrifluoride; With triethylamine; In dichloromethane; for 0.166667h; Inert atmosphere;

chloro-trimethyl-silane; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.8b03188

Reference yield: 94.0%

Nonafluorobutanesulfonyl fluoride (375-72-4) + 1-trifluoromethyl-4-trimethylsilyloxybenzene (41571-86-2) → trimethylsilyl fluoride (420-56-4) + 4-(trifluoromethyl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate (33073-26-6)

Guidance literature:

triethylamine; In neat (no solvent); in presence of a few HF, CsF, KF, (R4N)F, (C2H5)2NH, effectless in presence of pyridinp, NaF and NH4F;

upstream raw materials:

4-hydroxybenzotrifluoride

1,1,1,3,3,3-hexamethyl-disilazane

chloro-trimethyl-silane

Downstream raw materials:

4-(trifluoromethyl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

(R)-(-)-1-phenyl-1-(4-trifluoromethylphenoxy)-2-propene

trimethylsilyl fluoride

4-(4-(trifluoromethyl)phenoxy)benzonitrile

Refernces

• 1、 Blechta, Vratislav,Sabata, Stanislav,Sykora, Jan,Hetflejs, Jiri,Soukupova, Ludmila,Schraml, Jan. "The effect of solvent accessible surface on Hammett-type dependencies of infinite dilution 29Si and 13C NMR shifts in ring substituted silylated phenols dissolved in chloroform and acetone". experimental part. p. 128 - 134. Retrieved 2012/08/07.