1,3-DIETHYLTHYMINE

Base Information

• Chemical Name: 1,3-DIETHYLTHYMINE
• CAS No.: 21472-93-5
• Molecular Formula: C₉H₁₄N₂O₂
• Molecular Weight: 182.222
• Hs Code.: 2933599090
• Mol file: 21472-93-5.mol

Synonyms:Thymine,1,3-diethyl- (8CI);1,3-Diethylthymine;

Chemical Property of 1,3-DIETHYLTHYMINE

Chemical Property:

• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.493
• Boiling Point: 258.979 °C at 760 mmHg
• Flash Point: 101.418 °C
• PSA: 44.00000
• Density: 1.084 g/cm³
• LogP: 0.35820

Purity/Quality:

99% ^*data from raw suppliers

1,3-DIETHYLTHYMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-DIETHYLTHYMINE

There total 5 articles about 1,3-DIETHYLTHYMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl bromide (74-96-4) + thymin (65-71-4,28806-14-6,691841-57-3) → 1,3-diethylthymine (21472-93-5)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In benzene; at 80 ℃; for 32h;

Reference yield: 39.0%

diethyl sulfate (64-67-5) + 4-methoxy-5-methyl-pyrimidin-2(1H)-one (25902-89-0) → 2-ethoxy-4-methoxy-5-methylpyrimidine (905716-25-8) + 1-ethyl-4-methoxy-5-methyl-2(1H)-pyrimidinone + 1-ethyl-5-methyl-2,4(3H)-pyrimidindione (21472-94-6) + 1,3-diethylthymine (21472-93-5)

Guidance literature:

4-methoxy-5-methyl-pyrimidin-2(1H)-one; With lithium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 0.5h;

diethyl sulfate; In N,N-dimethyl-formamide; at 60 ℃; for 48h;

DOI:10.1016/j.tet.2006.04.098

Reference yield: 22.0%

ethyl iodide (75-03-6) + thymin (65-71-4,28806-14-6,691841-57-3) → 1-ethyl-5-methyl-2,4(3H)-pyrimidindione (21472-94-6) + 1,3-diethylthymine (21472-93-5)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1039/c8ob02552e

upstream raw materials:

diethyl sulfate

2,4-dihydroxy-5-methylpyrimidine

ethyl bromide

thymin

Refernces

• 1、 Michalak, Olga,Cmoch, Piotr,Krzeczyński, Piotr,Cybulski, Marcin,Le?, Andrzej. "A diversity of alkylation/acylation products of uracil and its derivatives: Synthesis and a structural study". . p. 354 - 362. Retrieved 2019/01/10.
• 2、 Hedayatullah, Mir. "Alkylation des pyrimidines en catalyse par transfert de phase". . p. 339 - 342. Retrieved 2007/10/02.