4-FLUOROANILINE HCL

Base Information

• Chemical Name: 4-FLUOROANILINE HCL
• CAS No.: 2146-07-8
• Molecular Formula: C6H6 F N . Cl H
• Molecular Weight: 147.58
• Hs Code.: 2921440000
• Mol file: 2146-07-8.mol

Synonyms:Aniline,p-fluoro-, hydrochloride (8CI); Benzenamine, 4-fluoro-, hydrochloride (9CI);4-Fluoroaniline hydrochloride; 4-Fluorobenzenamine hydrochloride;p-Fluoroaniline hydrochloride

Chemical Property of 4-FLUOROANILINE HCL

Chemical Property:

• Melting Point: >200 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 167 °C/27 mmHg
• PSA: 26.02000
• LogP: 2.79110
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoroaniline Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUOROANILINE HCL

There total 7 articles about 4-FLUOROANILINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-azidofluorobenzene (3296-02-4) → p-fluoroaniline hydrochloride (2146-07-8)

Guidance literature:

p-azidofluorobenzene; With 1,3-diphenyl-disiloxane; triphenylphosphine; at 20 ℃; for 24h;

With water;

With hydrogenchloride; In 1,4-dioxane; chemoselective reaction;

DOI:10.1021/acs.joc.9b00831

Reference yield: 98.0%

4-Fluoronitrobenzene (350-46-9,178603-76-4) → p-fluoroaniline hydrochloride (2146-07-8)

Guidance literature:

4-Fluoronitrobenzene; With iododioxobis(triphenylphosphine)rhenium(V); phenylsilane; In toluene; for 0.666667h; Reflux;

With hydrogenchloride; In diethyl ether; toluene;

DOI:10.1021/jo9008657

Reference yield: 73.0%

4'-fluoroacetanilide (351-83-7) + ethylmagnesium bromide (925-90-6) → p-fluoroaniline hydrochloride (2146-07-8) + butanone (78-93-3)

Guidance literature:

4'-fluoroacetanilide; With 2-fluoropyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at 0 ℃; for 0.5h;

ethylmagnesium bromide; With cerium(III) chloride; In tetrahydrofuran; dichloromethane; at -78 ℃; for 2h;

With hydrogenchloride; In ethyl acetate;

DOI:10.1016/j.cclet.2015.05.033

upstream raw materials:

4-Fluoronitrobenzene

4-fluoroaniline

dicyclohexylphosphinoyl chloride

4'-fluoroacetanilide

Downstream raw materials:

2,5-bis-(4-fluoro-anilino)-[1,4]benzoquinone-bis-(4-fluoro-phenylimine)

N-(4-fluoro-phenyl)-N'-(4-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-guanidine

1-isopropyl-5-(4-fluorophenyl)biguanide

1-(4-fluoro-phenyl)-5-isopropyl-biguanide; hydrochloride

Refernces

• 1、 Lenstra, Danny C.,Wolf, Joris J.,Mecinovi?, Jasmin. "Catalytic Staudinger Reduction at Room Temperature". . p. 6536 - 6545. Retrieved 2019/05/24.
• 2、 Ficker, Mario,Petersen, Johannes F.,Hansen, Jon S.,Christensen, Jorn B.. "Hydrogenation of aromatic nitro compounds with an inexpensive and efficient CuSO4/CoCl2 catalyst prepared in situ using NaBH 4 as the hydrogen source". . p. 176 - 182. Retrieved 2014/04/17.