7-Bromo-2-methyl-5-phenyl-heptanoic acid ethyl ester

Base Information

• Chemical Name: 7-Bromo-2-methyl-5-phenyl-heptanoic acid ethyl ester
• CAS No.: 188670-37-3
• Molecular Formula: C₁₆H₂₃BrO₂
• Molecular Weight: 327.261
• Mol file: 188670-37-3.mol

Synonyms:7-Bromo-2-methyl-5-phenyl-heptanoic acid ethyl ester

Chemical Property of 7-Bromo-2-methyl-5-phenyl-heptanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Bromo-2-methyl-5-phenyl-heptanoic acid ethyl ester

There total 8 articles about 7-Bromo-2-methyl-5-phenyl-heptanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenylglutaric acid anhydride (4160-80-9) → 7-Bromo-2-methyl-5-phenyl-heptanoic acid ethyl ester (188670-37-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 19 percent / NaBH₄ / tetrahydrofuran / 1 h / 0 deg C to rt

2: 69 percent / n-butyllithium, DIBAL / tetrahydrofuran; toluene; hexane / -78 deg C; rt

3: H₂ / Pd/C

4: Et₃N / CH₂Cl₂

5: LiBr / acetone / Heating

With sodium tetrahydroborate; n-butyllithium; hydrogen; diisobutylaluminium hydride; triethylamine; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; acetone; toluene;

DOI:10.1139/v96-279

Reference yield:

4-phenyltetrahydropyran-2-one (61198-49-0,61949-75-5,71302-21-1,25547-53-9) → 7-Bromo-2-methyl-5-phenyl-heptanoic acid ethyl ester (188670-37-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 69 percent / n-butyllithium, DIBAL / tetrahydrofuran; toluene; hexane / -78 deg C; rt

2: H₂ / Pd/C

3: Et₃N / CH₂Cl₂

4: LiBr / acetone / Heating

With n-butyllithium; hydrogen; diisobutylaluminium hydride; triethylamine; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; acetone; toluene;

DOI:10.1139/v96-279

Reference yield:

3-phenylglutaric acid (4165-96-2) → 7-Bromo-2-methyl-5-phenyl-heptanoic acid ethyl ester (188670-37-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 98 percent / acetic anhydride / 2 h / Heating

2: 19 percent / NaBH₄ / tetrahydrofuran / 1 h / 0 deg C to rt

3: 69 percent / n-butyllithium, DIBAL / tetrahydrofuran; toluene; hexane / -78 deg C; rt

4: H₂ / Pd/C

5: Et₃N / CH₂Cl₂

6: LiBr / acetone / Heating

With sodium tetrahydroborate; n-butyllithium; hydrogen; diisobutylaluminium hydride; triethylamine; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; acetic anhydride; acetone; toluene;

DOI:10.1139/v96-279

upstream raw materials:

4-phenyltetrahydropyran-2-one

3-phenylglutaric acid anhydride

3-phenylglutaric acid

2-phenyl-propane-1,1,3-tricarboxylic acid triethyl ester

Refernces